SynthesisFrontiers in pharmacology2025
A systematic review and meta-analysis on how different dexamethasone administration regimes impact total joint arthroplasty outcomes.
Synthesis in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Optimizing perioperative systemic dexamethasone use in total knee arthroplasty: a narrative review on current evidence.Knee surgery & related research · 2026Review
- Nanotechnology-driven delivery of dexamethasone for arthritis: The role of liposomes.EXCLI journal · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Postoperative pain following total joint arthroplasty is a critical factor influencing patient recovery. This meta-analysis evaluated the efficacy and safety of single-dose, repeated-dose, and split-dose perioperative dexamethasone regimens for managing postoperative pain in patients undergoing total joint arthroplasty. Methods: Randomized controlled studies (RCTs) comparing repeated or split-dexamethasone to single intravenous dexamethasone in patients having total knee/hip arthroplasty were retrieved from Pubmed, the Cochrane Library, Web of Science and Embase databases from inception to October 2024. Using RevMan 5.2, a meta-analysis was performed to evaluate primary outcomes including pain scores, length of stay, and incidence of postoperative rescue analgesia, as well as secondary outcomes such as the incidence of adverse events. Heterogeneity was assessed via I Results: Twelve trials were included. The results showed that repeated-dose dexamethasone did not differ from single-dose dexamethasone in rest or movement pain scores at 24 h, but significantly reduced both rest (mean difference [MD] = -0.45, 95% confidence interval [CI]: -0.62 to -0.29, Conclusion: Compared to patients receiving a single-dose or split-dose of dexamethasone, the administration of repeated doses of dexamethasone can mitigate postoperative pain, reduce the requirement for supplementary opioids, shorten the duration of hospitalization, and decrease the incidence of PONV following arthroplasty. Systematic Review Registration: https://inplasy.com/inplasy-2023-10-0023/.
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