Evidence map›Paper›PMID 40678723›Full record

ReviewFrontiers in pharmacology2025

Adenosine and adenosine receptors: a "double-edged sword" in cardiovascular system.

Yongqi Qian, Yixuan Zheng, Liang Leng, Qingqing Liu, Xiaojuan Tian, Shilin Chen, Sanyin Zhang, Jiang Xie

Abstract readReview
In one paragraph

Review in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yongqi Qian *School of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Yixuan Zheng *Institute of Herbgenomics, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Liang LengInstitute of Herbgenomics, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Qingqing LiuSchool of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Xiaojuan TianSchool of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Shilin ChenInstitute of Herbgenomics, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Sanyin ZhangInnovative Institute of Chinese Medicine and Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Jiang XieSchool of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adenosine serves a variety of biological purposes in the circulatory system and was first discovered in the heart in 1929. By interacting with four adenosine receptor (AR) subtypes of G protein-coupled receptors-A

Indexed as

adenosineadenosine receptorscardiovascular systemcontradictorytarget

Identifiers

PMID40678723
PMCPMC12267028

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.