Evidence map›Paper›PMID 40678693›Full record

ArticleBiological psychiatry global open science2025

Prepronociceptin-Expressing Neurons in the Bed Nucleus of the Stria Terminalis Signal Escape Behavior.

Maria M Ortiz-Juza, Randall L Ung, Sophia M Hegel, Ayden L Ring, Noah W Miller, Ruben A Garcia-Reyes, Hiroshi Nomura, Hiroyuki K Kato, Nicolas C Pégard, Jose Rodriguez-Romaguera

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biological psychiatry global open science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Maria M Ortiz-JuzaNeuroscience Curriculum, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Randall L UngDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Sophia M HegelDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Ayden L RingDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Noah W MillerNeuroscience Curriculum, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Ruben A Garcia-ReyesDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Hiroshi NomuraEndowed Department of Cognitive Function and Pathology, Institute of Brain Science, Graduate School of Medical Science, Nagoya City University, Nagoya, Japan.
Hiroyuki K KatoDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Nicolas C PégardDepartment of Applied Physical Sciences, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Jose Rodriguez-RomagueraDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

Funding

Encoding social arousal within prepronociceptin circuits in the extended amygdalaR01MH132073 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Jose Rodriguez-Romaguera · 2023 to 2026
$2.7M
NIMH NIH HHS R01 MH132073
6 · The paper itself

Abstract

Background: Dysregulation in neural circuits that encode arousal responses to aversive stimuli is thought to contribute to changes in motivated behaviors associated with neuropsychiatric disorders. However, the relationship between arousal and motivation remains poorly understood. We previously identified that prepronociceptin-expressing neurons in the bed nucleus of the stria terminalis ( Methods: In this study, we investigated the role of Results: We found that the bulk activity of Conclusions: These results highlight a novel role of

Indexed as

Aversive stimuliBed nucleus of the stria terminalisCalcium imagingEscape behaviorOdor preference testPrepronociceptin

Identifiers

PMID40678693
PMCPMC12268543

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.