Evidence map›Paper›PMID 40678611›Full record

ArticleJournal of orthopaedic translation2025

Relieving oxidative stress microenvironment and promoting vascularized bone formation to treat femoral head necrosis using 3D-printed scaffold with ultralong-term multienzyme-like activity.

Xiaobo Xie, Jinwei Zhang, Jianxiong Shu, Zhaoran Wu, Chengqiang Wang, Zhifei Gao, Zhenwen Huang, Lihua Li, Jieli Chen, Yao Lu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of orthopaedic translation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Glucose metabolism in osteoporosis: A potential therapeutic target (Review).International journal of molecular medicine · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xiaobo XieDepartment of Joint and Orthopedics, Orthopedic Center, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, 510282, China.
Jinwei ZhangDepartment of Orthopedics, General Hospital of Southern Theatre Command of PLA, Southern Medical University, Guangzhou, Guangdong, 510010, China.
Jianxiong ShuDepartment of Joint and Orthopedics, Orthopedic Center, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, 510282, China.
Zhaoran WuDepartment of Joint and Orthopedics, Orthopedic Center, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, 510282, China.
Chengqiang WangDepartment of Spine Surgery, Orthopedic Center, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, 510282, China.
Zhifei GaoThe Second School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, 510282, China.
Zhenwen HuangDepartment of Joint and Orthopedics, Orthopedic Center, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, 510282, China.
Lihua LiFuture Institute of Technology, Guangdong Provincial Key Laboratory of Nanophotonic Functional Materials and Devices, Guangdong Basic Research Center of Excellence for Structure and Fundamental Interactions of Matter, School of Information and Optoelectronic Science and Engineering, South China Normal University, Guangzhou, 510006, China.
Jieli ChenClinical Research Center, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, 510282, China.
Yao LuDepartment of Joint and Orthopedics, Orthopedic Center, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, 510282, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Characterized by microcirculatory disorder and oxidative stress microenvironment, the repair of bone defect after hip preservation therapy (such as core decompression) for osteonecrosis of the femoral head (ONFH) remains a clinical challenge. Thus, an ideal bone scaffold for treating ONFH should not only promote bone and vessel formation but also alleviate hypoxia and oxidative stress. Method: We integrated manganese oxides (MnO Results: The resultant MnO Conclusion: The 3D-printed MnO Translational potential of this article: PLGA has been already applied in clinical bone implants. Mn is an essential trace element for the human body and MnO

Indexed as

3D-printingEnzyme-like activityManganese oxides nanoparticlesOsteonecrosis of the femoral headPLGA

Identifiers

PMID40678611
PMCPMC12269450

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.