Evidence map›Paper›PMID 40678599›Full record

ArticleRespiratory medicine case reports2025

Case report and comprehensive literature review: A rare instance of solitary extramedullary plasmacytoma in the trachea.

Man Wang, Lu Liu, Shihuan Yu

Abstract readCase Reports
In one paragraph

Article in Respiratory medicine case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

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5 · Who and what money

Authors and funding

3 authors.

Man WangDepartment of Respiratory Medicine, The First Affiliated Hospital of Harbin Medical University, Harbin, 150001, China.
Lu LiuDepartment of Respiratory Medicine, The First Affiliated Hospital of Harbin Medical University, Harbin, 150001, China.
Shihuan YuDepartment of Respiratory Medicine, The First Affiliated Hospital of Harbin Medical University, Harbin, 150001, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This case report describes a rare instance of isolated extramedullary plasmacytoma in the trachea of a 69-year-old female who presented with acute respiratory distress 1 h prior to admission. Chest computed tomography (CT) revealed a nodular lesion within the trachea, characterized by marginal calcification and severe stenosis of the tracheal lumen. Fiberoptic bronchoscopy demonstrated that the nodular lesion significantly obstructed the airway lumen. The patient underwent a technically demanding endoscopic tumor debulking procedure. Histopathological examination via endoscopic biopsy confirmed the diagnosis of plasmacytoma. Further diagnostic imaging, including positron emission tomography-computed tomography (PET-CT), showed abnormal fluorodeoxyglucose (FDG) uptake within the lesion. Bone marrow aspiration smear and biopsy excluded multiple myeloma. Postoperatively, the patient's symptoms markedly improved, and she was discharged on the day of surgery. One month after the procedure, follow-up chest CT and bronchoscopy indicated partial residual tumor without evidence of local recurrence. The patient reported significant improvement in respiratory function and subsequently received radiotherapy targeting the local lesion. Regular follow-up after radiotherapy confirmed no recurrence of the lesion. A literature review indicates that extramedullary plasmacytoma (EMP) is uncommon and predominantly affects the upper respiratory and digestive tracts. Diagnosis typically involves histopathological analysis, bronchoscopic evaluation, and advanced imaging techniques. Treatment strategies are tailored based on the patient's clinical presentation and tumor characteristics. This case underscores the importance of considering intratracheal plasmacytoma in the differential diagnosis of obstructive tracheal masses and highlights the critical role of timely endoscopic tumor debulking in relieving airway obstruction and facilitating subsequent treatment.

Indexed as

Plasma cell tumorSolitary extramedullary plasma cell tumorTracheal tumor

Identifiers

PMID40678599
PMCPMC12269861

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