Evidence map›Paper›PMID 40678584›Full record

ArticleJournal of extracellular biology2025

Cargo Analysis and MRI-Based Therapeutic Assessment of Iron Oxide Labelled Extracellular Vesicles of Hypoxia Human Stem Cells in Ischemic Stroke.

Shannon Helsper, Li Sun, Richard Jeske, Chang Liu, Jacob Athey, Xuegang Yuan, Samuel C Grant, Yan Li

Abstract read
In one paragraph

Article in Journal of extracellular biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shannon HelsperChemical & Biomedical Engineering, FAMU-FSU College of Engineering Florida State University Tallahassee Florida USA.
Li SunChemical & Biomedical Engineering, FAMU-FSU College of Engineering Florida State University Tallahassee Florida USA.ORCID https://orcid.org/0000-0001-8228-7487
Richard JeskeChemical & Biomedical Engineering, FAMU-FSU College of Engineering Florida State University Tallahassee Florida USA.
Chang LiuChemical & Biomedical Engineering, FAMU-FSU College of Engineering Florida State University Tallahassee Florida USA.
Jacob AtheyChemical & Biomedical Engineering, FAMU-FSU College of Engineering Florida State University Tallahassee Florida USA.
Xuegang YuanChemical & Biomedical Engineering, FAMU-FSU College of Engineering Florida State University Tallahassee Florida USA.
Samuel C GrantChemical & Biomedical Engineering, FAMU-FSU College of Engineering Florida State University Tallahassee Florida USA.ORCID https://orcid.org/0000-0001-7738-168X
Yan LiChemical & Biomedical Engineering, FAMU-FSU College of Engineering Florida State University Tallahassee Florida USA.ORCID https://orcid.org/0000-0002-5938-8519

Funding

Engineering Extracellular Vesicles of Human Brain Organoids for Stroke TherapyR01NS125016 · NINDS · FLORIDA STATE UNIVERSITY · PI Yan Li · 2022 to 2026
$1.8M
MR Analysis of Pre-Conditioned Human Mesenchymal Stem Cells for Stroke TherapyR01NS102395 · NINDS · FLORIDA STATE UNIVERSITY · PI GRANT, SAMUEL COLLES · 2017 to 2021
$1.7M
Investigation into hMSC-derived therapy in ischemic stroke at high field MRimaging and spectroscopyF31NS115409 · NINDS · FLORIDA STATE UNIVERSITY · PI HELSPER, SHANNON · 2020 to 2022
$116k
NINDS NIH HHS F31 NS115409NINDS NIH HHS R01 NS102395NINDS NIH HHS R01 NS125016
6 · The paper itself

Abstract

Human mesenchymal stem cells (hMSCs) have been under investigation in preclinical and clinical settings for treating neurological disorders in recent years. Predominantly due to paracrine effects

Indexed as

extracellular vesicleshuman mesenchymal stem cellshypoxiaischemiamagnetic resonance imaging

Identifiers

PMID40678584
PMCPMC12269532

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.