ArticleGynecologic oncology reports2025
Intraepithelial lesions of the uterine cervix during pregnancy: reaffirming the safety of conservative management.
Article in Gynecologic oncology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Approaches to Intraepithelial Cervical Neoplasia Management in Pregnancy: A Narrative Review.Life (Basel, Switzerland) · 2026Review
- The significance of biological samples from pregnant women in cervical intraepithelial neoplasia.Frontiers in medicine · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives: Diagnosis of high-grade squamous intraepithelial lesions (HGSIL) during pregnancy is not uncommon, and managing these cases presents clinical challenges. In this study we evaluated the safety and outcomes of conservative management for high-grade squamous intraepithelial lesions (HGSIL) diagnosed during pregnancy. Methods: A retrospective case series was conducted at Soroka University Medical Center (2011-2020) including pregnant women with histologically confirmed HGSIL managed conservatively during pregnancy and treated postpartum. Results: Thirty-two women were included. The mean age at diagnosis was 31.2 ± 3.4 years, with most diagnosed in the first trimester (mean gestational age 8.1 ± 4.1 weeks). The average gestational age at delivery was 39.3 ± 1.0 weeks, and mean birth weight was 3045.6 ± 501.7 g. Postpartum conization showed complete regression in 15.6 %, regression to LGSIL in 6.3 %, and persistent HGSIL in 78.1 %. No cases progressed to invasive cancer. During 5.7 ± 2.9 years of follow-up, three patients (9.4%) experienced recurrence requiring repeat conization. Conclusions: Conservative management of HGSIL during pregnancy appears to be a safe and effective approach. In our case series, no progression to malignancy was observed, and postpartum outcomes were favourable. Deferring excisional treatment until after delivery is supported by these findings
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