ArticleFrontiers in cardiovascular medicine2025
Hospitalized patients and stimulant use-associated heart failure: importance of ejection fraction and related risk factors.
Article in Frontiers in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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14 authors.
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Abstract
Background: Methamphetamine and cocaine use are known risk factors for heart failure (HF). Previous studies focused on HF cases identified as either methamphetamine or cocaine-induced HF with no study identifying the HF subtype most associated with stimulant use. Our study hypothesizes that stimulant users have a higher odds of developing HFrEF than HFpEF. Our study also compares demographic and comorbidities between the HF subtypes. Methods: National Inpatient Sample data from 2008 to 2020 were used to identify hospital admissions among stimulant users with HF. The chi-square test for categorical variables and Results: Stimulant use was more likely to be associated with HFrEF (OR = 1.97, CI 1.93-2.01), while less associated with HFpEF (OR = 0.96, CI 0.94-0.98). HF among stimulant users was common ( Conclusion: Stimulant use is positively associated with HFrEF, with the highest risk being in those middle-aged, male, Black, or covered by Medicaid. The higher likelihood of traditional risk factors for HF in stimulant-related HF supports the hypothesis that stimulants induce multifactorial damage to the cardiovascular system.
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