Evidence map›Paper›PMID 40678530›Full record

ArticleiScience2025

Altered cofactor recruitment and nucleosome dynamics underlie bisphenol A's impact on ERα-mediated transcriptional bursting.

Christopher R Day, Pelin Yaşar, Gloria Adedoyin, Brian D Bennett, Carson C Chow, Joseph Rodriguez

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Christopher R DayEpigenetics and RNA Biology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, Durham, NC 27709, USA.
Pelin YaşarEpigenetics and RNA Biology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, Durham, NC 27709, USA.
Gloria AdedoyinEpigenetics and RNA Biology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, Durham, NC 27709, USA.
Brian D BennettIntegrative Bioinformatics Support Group, Biostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, Durham, NC 27709, USA.
Carson C ChowLaboratory of Biological Modeling, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD 20892, USA.
Joseph RodriguezEpigenetics and RNA Biology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, Durham, NC 27709, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Transcription initiation at hormone-responsive gene promoters involves recruitment of numerous proteins that initiate stochastic events known as transcriptional bursts. Estrogen responsive genes are regulated by Estradiol (E2) that binds to the Estrogen Receptor-α (ERα), allowing ERα to interact with DNA regulatory elements, recruit cofactors, and initiate transcription. Here, we utilized single-molecule imaging to determine how ERα mediated transcription is altered by non-canonical ligands such as Bisphenol A (BPA). Our analysis showed that the

Indexed as

BiochemistryMolecular biologyMolecular interaction

Identifiers

PMID40678530
PMCPMC12268693

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.