Evidence map›Paper›PMID 40678521›Full record

ArticleiScience2025

Dietary fermentable polyols fuel gut inflammation through M1 macrophage polarization and gut microbiota.

Kensuke Sato, Miwa Tomioka, Masahiro Akiyama, Yasuyuki Matsuda, Hideki Hara, Haruki Sasa, Yosuke Kurashima, Joe Inoue, Shinji Fukuda, Yun-Gi Kim

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kensuke SatoResearch Center for Drug Discovery, Faculty of Pharmacy and Graduate School of Pharmaceutical Sciences, Keio University, Tokyo 105-8512, Japan.
Miwa TomiokaResearch Center for Drug Discovery, Faculty of Pharmacy and Graduate School of Pharmaceutical Sciences, Keio University, Tokyo 105-8512, Japan.
Masahiro AkiyamaResearch Center for Drug Discovery, Faculty of Pharmacy and Graduate School of Pharmaceutical Sciences, Keio University, Tokyo 105-8512, Japan.
Yasuyuki MatsudaDepartment of Infectious Diseases, Division of Microbiology and Immunochemistry, Asahikawa Medical University, Hokkaido 078-8510, Japan.
Hideki HaraDepartment of Infectious Diseases, Division of Microbiology and Immunochemistry, Asahikawa Medical University, Hokkaido 078-8510, Japan.
Haruki SasaDepartment of Innovative Medicine, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
Yosuke KurashimaInstitute for Advanced Academic Research, Chiba University, Chiba 260-8670, Japan.
Joe InoueDivision of Biochemistry, Faculty of Pharmacy and Graduate School of Pharmaceutical Sciences, Keio University, Tokyo 105-8512, Japan.
Shinji FukudaInstitute for Advanced Biosciences, Keio University, Yamagata 997-0052, Japan.
Yun-Gi KimDepartment of Microbiology, School of Pharmacy, Kitasato University, Tokyo 108-8641, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

While fermentable oligo- and di-, mono-saccharides and polyols (FODMAPs) have been implicated in exacerbating inflammatory bowel disease (IBD) symptoms, the exact influence of FODMAPs on gut microbiota and inflammation is unclear. Here, we show that sorbitol, a polyol, exacerbates colitis in mice induced by dextran sodium sulfate (DSS). Sorbitol increases the expression of inflammatory genes, including

Indexed as

Clinical microbiologyHealth sciencesMicrobiomeMolecular microbiology

Identifiers

PMID40678521
PMCPMC12270690

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.