Evidence map›Paper›PMID 40678517›Full record

ArticleiScience2025

Gpr37 modulates the severity of inflammation-induced GI dysmotility by regulating enteric reactive gliosis.

Keiramarie Robertson, Oliver Hahn, Adarsh Tantry, Beatriz G Robinson, Arwa T Faruk, Mathangi Janakiraman, Hong Namkoong, Kwangkon Kim, Jiayu Ye, Estelle Spear Bishop and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Keiramarie RobertsonNeurosciences Graduate Program, Stanford University, Stanford, CA, USA.
Oliver HahnWu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA.
Adarsh TantryNeurosciences Graduate Program, Stanford University, Stanford, CA, USA.
Beatriz G RobinsonNeurosciences Graduate Program, Stanford University, Stanford, CA, USA.
Arwa T FarukDepartment of Human Biology, Stanford University, Stanford, CA, USA.
Mathangi JanakiramanDepartment of Medicine, Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Hong NamkoongDepartment of Medicine, Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Kwangkon KimDepartment of Medicine, Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Jiayu YeDepartment of Medicine, Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Estelle Spear BishopDepartment of Medicine, Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Randy A HallDepartment of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, GA, USA.
Tony Wyss-CorayWu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA.
Laren BeckerDepartment of Medicine, Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Julia A KaltschmidtWu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA.

Funding

Training Program in Basic NeuroscienceT32MH020016 · NIMH · STANFORD UNIVERSITY · PI Justin L Gardner, Merritt C Maduke · 1997 to 2026
$16.2M
Development and Patterning of the Enteric Nervous SystemR21HD110950 · NICHD · STANFORD UNIVERSITY · PI KALTSCHMIDT, JULIA ANNA · 2023 to 2023
$431k
NICHD NIH HHS R21 HD110950NIMH NIH HHS T32 MH020016
6 · The paper itself

Abstract

The enteric nervous system (ENS) is contained within two layers of the gut wall and is made up of neurons and enteric glial cells (EGCs) that regulate gastrointestinal (GI) function. EGCs in both inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS) change in response to inflammation, referred to as reactive gliosis. Whether EGCs restricted to a specific layer or region within the GI tract alone can influence intestinal immune response is unknown. Using bulk RNA-sequencing and

Indexed as

ImmunityMolecular biologyNeuroscience

Identifiers

PMID40678517
PMCPMC12269290

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.