ArticleiScience2025
The lateral habenula contributes to regulation of body temperature.
Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- PGE2 modulation of stimulus valence directs zebrafish behavioral fever.bioRxiv : the preprint server for biology · 2026Article
- Behavioral and circuit principles of temperature gradient navigation.Current biology : CB · 2025Article
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Authors and funding
13 authors.
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Abstract
The lateral habenula (LHb) is implicated in the regulation of numerous physiological functions, particularly those associated with thermoregulation. It exhibits close anatomical and functional connections with the key brain regions that play a crucial role in regulating body temperature. However, whether the LHb directly contributes to temperature regulation remains unclear. We here report that chemogenetic and optogenetic manipulations of LHb glutamatergic neurons bidirectionally modulated body temperature. When the LHb glutamatergic neurons were impaired, mice exhibited a pronounced intolerance to cold stimuli. Interestingly, we observed differential responses to thermal stimuli between GABAergic neurons in LPO and glutamatergic neurons in LHb. Notably, cold-activated glutamatergic neurons in LHb receive the projections from heat-activated GABAergic neurons in LPO. Using optogenetic techniques to activate the LPO
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