ArticleiScience2025
Lattice bond chains administer kink anisotropy and inform strategies of theophylline crystal self-healing.
Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
How molecular-level understanding of the crystal growth mechanisms and their relation to lattice bonds informs the rational design of crystals with desired shapes and properties has remained elusive. Here we employ theophylline crystals and drive them into classical growth mode, in which the crystals grow molecule-by-molecule and new layers are generated by two-dimensional nucleation. We demonstrate that classical growth allows for controlling the crystal's shape and dimensions. We correlate the anisotropic responses to the supersaturation of the growth rates of crystal layers and crystal faces to the hydrogen and π-π stacking bond chains in the crystal lattice. The obtained insights suggest strategies to direct the crystal shape to either one-dimensional needles or flat sheets. Moreover, we show that crystals that grow by the classical mode of direct monomer incorporation have the potential to regrow and heal once a defect is introduced by mechanical cut or local thermal subliming of crystalline sections.
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