ArticleOpen forum infectious diseases2025
Performance (Sensitivity and Specificity) of a New Point-of-Care Immunochromatography to Screen for Imported Chronic Schistosomiasis Among Long-Term Sub-Saharan Migrants.
Article in Open forum infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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17 authors.
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Abstract
Background: Imported schistosomiasis is underdiagnosed among long-term migrants in non-endemic countries. Reference standard tests are lacking for the diagnosis of chronic schistosomiasis. Methods: This study evaluated the sensitivity and specificity of a new immunochromatography (ICT) test using serum (s) or point-of-care finger-prick (FP) whole blood against standard serological tests in long-term migrants from sub-Saharan Africa. Results: A total of 202 individuals were screened, with a mean age of 42.7 years. Of these, 75.7% were male, and 42.6% were from Senegal. Test positivity rates were 15.8% for ELISA, 24.3% for ICT-p, 46.5% for ICT-b (s), and 28.7% for ICT-b (FP). All tests showed good agreement with a clinical score but with heterogeneous agreement between them. Our results indicates a higher sensitivity for ICT-b (s). Positive responses after treatment suggest good specificity for all tests. Conclusions: ICT-b (s) shows a higher sensitivity than the other standard tests. An ICT-b (FP) strategy could be used as a first-step point-of-care screening tool for probable chronic schistosomiasis.
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