ArticleFrontiers in endocrinology2025
Single-center prospective study on thyroid function outcomes and neurological prognoses at 3 years of age in children with mild neonatal hyperthyrotropinemia.
Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To explore early management strategies for full-term neonates with TSH 5-10 mU/L and normal FT4. Methods: In this single-center longitudinal prospective study, 88 neonates diagnosed at 7-14 days were followed to age three. Results: 94.3% (83/88) had transient TSH elevation; 77 normalized within two months without treatment, while six received levothyroxine (3-5µg/kg/day). Five neonates (5.7%) exhibited persistent hyperthyrotropinemia and had significantly higher initial TSH. No hyperthyroidism was observed. Following up to 3 years old, only one child (1/81, 1.2%) exhibited development delay in personal-social development. Neonates with transient hyperthyrotropinaemia scored higher in problem-solving and personal-social domains than those with persistent hyperthyrotropinaemia. Neonatal FT4 at 7-14 days, timing of TSH normalization, and maternal early-pregnancy FT4 influenced the neurodevelopment of neonates. Infants of mothers with gestational diabetes scored lower in the personal-social domain. Conclusions: Persistent hyperthyrotropinemia occurs in 5.7% of mild cases and is associated with higher initial TSH. Levothyroxine at 3-5 µg/kg/day is both adequate and safe. The majority of neonates got a normal neurodevelopment by age 3, and the subtle difference between transient and persistent hyperthyrotropinemia was impacted by both maternal and neonatal factors.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.