ArticleArchives of rehabilitation research and clinical translation2025
Safety and Effectiveness of Early Rehabilitation in Patients With Stroke and Concomitant Kidney Disease: A Cohort Study With Claims Data.
Article in Archives of rehabilitation research and clinical translation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objectives: To evaluate the effectiveness and safety of early rehabilitation started within 24 to 48 hours in patients with stroke and chronic kidney disease (CKD). Design: Database cohort study. Setting: Acute hospital. Participants: The study included patients with stroke (n=21,061) and concomitant CKD who were admitted to an acute hospital between April 1, 2018, and March 31, 2020, including those with CKD who underwent early rehabilitation (n=10,129) and usual care (n=2702), as well as those with end-stage kidney disease (ESKD) who underwent early rehabilitation (n=3086) and usual care (n=954). The mean (standard deviation) age of the population was 76.5 (11.1) years, and the sex distribution was 67.3% men and 32.7% women. Main Outcome Measures: The primary outcome was hospitalization-related mortality, and the secondary outcomes included changes in activities of daily living, measured using the Barthel Index, and length of hospital stay. Results: Early rehabilitation was no associated with increase in mortality risk (hazard ratio [HR], 0.82; 95% confidence interval (95% CI), 0.67-1.02; Conclusions: This study supports the safety of implementing early rehabilitation in patients with stroke and CKD. Moreover, early rehabilitation may reduce mortality in patients requiring long-term hospitalization.
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