Evidence map›Paper›PMID 40678253›Full record

ArticleResearch square2025

Effect of calcium oxalate microcrystals on kidney proximal tubule epithelial cell gene expression in microgravity.

Kendan Jones-Isaac, Catherine K Yeung, Jacelyn Bain, Kevin Lidberg, Jade Yang, Lu Wang, James MacDonald, Theo Bammler, Kenneth E Thummel, Megan Corn and 5 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Kendan Jones-IsaacUniversity of Washington.
Catherine K YeungUniversity of Washington.
Jacelyn BainUniversity of Washington.
Kevin LidbergUniversity of Washington.
Jade YangUniversity of Washington.
Lu WangSciences University of Washington.
James MacDonaldSciences University of Washington.
Theo BammlerSciences University of Washington.
Kenneth E ThummelUniversity of Washington.
Megan CornUniversity of Washington.
Micaela Vela RuizUniversity of Washington.
Stefanie CountrymanUniversity of Colorado.
Paul KoenigUniversity of Colorado.
Jonathan HimmelfarbMt Sinai School of Medicine.
Edward J KellyUniversity of Washington.

Funding

XENOBIOTIC BIOTRANSFORMATION AND DISPOSITIONP30ES007033 · NIEHS · UNIVERSITY OF WASHINGTON · PI Nicole Ann Errett · 1995 to 2026
$42.5M
Environmetal Pathology/Toxicology Training ProgramT32ES007032 · NIEHS · UNIVERSITY OF WASHINGTON · PI FAUSTMAN, ELAINE M, ROSENFELD, MICHAEL E · 1985 to 2023
$10.7M
Using iPSCs to model patient outcomes in nephrotic syndromeUH3TR000504 · NCATS · UNIVERSITY OF WASHINGTON · PI HIMMELFARB, JONATHAN · 2014 to 2016
$6.1M
A Microphysiological System for Kidney Disease Modeling and Drug Efficacy TestingUG3TR002158 · NCATS · UNIVERSITY OF WASHINGTON · PI HIMMELFARB, JONATHAN · 2017 to 2018
$2.9M
Effects of microgravity on the structure and function of proximal and distal tubule MPSUH3TR002178 · NCATS · UNIVERSITY OF WASHINGTON · PI HIMMELFARB, JONATHAN, KELLY, EDWARD J · 2019 to 2020
$842k
Effects of microgravity on the structure and function of proximal and distal tubule MPSUG3TR002178 · NCATS · UNIVERSITY OF WASHINGTON · PI HIMMELFARB, JONATHAN, KELLY, EDWARD J · 2017 to 2018
$769k
NCATS NIH HHS UG3 TR002158NCATS NIH HHS UG3 TR002178NCATS NIH HHS UH3 TR000504NCATS NIH HHS UH3 TR002178NIEHS NIH HHS P30 ES007033NIEHS NIH HHS T32 ES007032
6 · The paper itself

Abstract

We evaluated the impact of spaceflight on a microphysiologic model of calcium oxalate (CaOx) kidney stone disease. Proximal tubule epithelial cells cultured as confluent microtubules were exposed to CaOx crystals with or without potassium citrate (a potential countermeasure) to determine impact on gene expression. Nine genes were differentially expressed in response to CaOx crystal exposure during spaceflight. This project presents the use of microgravity as a unique environment to study kidney pathophysiology.

Identifiers

PMID40678253
PMCPMC12270224

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.