Evidence map›Paper›PMID 40678234›Full record

ArticleResearch square2025

Performance of the low-cost phenotypic thin-layer agar MDR/XDR-TB Colour Test (first generation, 1G, Color Plate Test) for identifying drug-resistant Mycobacterium tuberculosis isolates in a resource-limited setting.

Binyam Mebrat, Juan I Garcia, Yimtubezenash Woldeamanuel, Kelemework Adane, Amberlee Hicks, Melaku Tilahun, Sebsib Neway, Lelisa Oluma, Abay Atnafu, Jonathan Gelfond and 4 more

Abstract readPreprint
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Binyam MebratArmauer Hansen Research Institute (AHRI).
Juan I GarciaTexas Biomedical Research Institute.
Yimtubezenash WoldeamanuelAddis Ababa University.
Kelemework AdaneAddis Ababa University.
Amberlee HicksTexas Biomedical Research Institute.
Melaku TilahunArmauer Hansen Research Institute (AHRI).
Sebsib NewayArmauer Hansen Research Institute (AHRI).
Lelisa OlumaArmauer Hansen Research Institute (AHRI).
Abay AtnafuArmauer Hansen Research Institute (AHRI).
Jonathan GelfondUT Health San Antonio.
Carlton A EvansIFHAD: Innovation for Health And Development, Imperial College London.
Jordi B TorrellesTexas Biomedical Research Institute.
Shu-Hua WangTexas Biomedical Research Institute.
Liya WassieArmauer Hansen Research Institute (AHRI).

Funding

Interdisciplinary NexGen TB research Advancement Center (IN-TRAC)P30AI168439 · NIAID · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI JOANNE TURNER · 2022 to 2026
$6.9M
Improving rapid phenotypic drug susceptibility testing for drug resistant tuberculosis in high-burden areasR01AI176309 · NIAID · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI BLANCA I RESTREPO, Jordi B Torrelles · 2023 to 2026
$3.5M
Ethiopia-Emory TB Research Training ProgramD43TW009127 · FIC · EMORY UNIVERSITY · PI HENRY M BLUMBERG, Kidist Bobosha · 2013 to 2026
$3.4M
Determining the efficacy of a novel TB diagnostic test to monitor treatment success in drug resistant TB patientsR21AI150445 · NIAID · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI GARCIA-BASTEIRO, ALBERTO, TORRELLES, JORDI B · 2020 to 2021
$423k
FIC NIH HHS D43 TW009127NIAID NIH HHS P30 AI168439NIAID NIH HHS R01 AI176309NIAID NIH HHS R21 AI150445Wellcome Trust
6 · The paper itself

Abstract

Background: The accessible, easy to use and timely, diagnosis of tuberculosis (TB) drug-susceptibility, including multi-drug resistant (MDR-) TB and extensively-drug resistant (XDR-)TB is often challenging, particularly in resource-constrained settings. We therefore evaluated the phenotypic thin-layer agar based MDR/XDR-TB Colour Test, which is also referred to as the "First Generation (1G) Color Plate Test (TB-CX)" performance for detecting resistance of Methods: A cross-sectional study was conducted on Results: The median (range) times in days determining Conclusion: The accuracy of

Indexed as

diagnosisdrug-resistant TBdrug susceptibility testFirst generation (1G) Color Plate TestMDR/XDR-TB Colour TestMycobacterium tuberculosisthin-layer agar

Identifiers

PMID40678234
PMCPMC12270243

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.