Evidence map›Paper›PMID 40678229›Full record

ArticleResearch square2025

Mature Human Bone Marrow Plasma Cells Secrete More IgG than Early-Minted Blood Antibody-Secreting Cells.

Doan C Nguyen, Ian T Hentenaar, Monica Cabrera-Mora, Shuya Kyu, Andrea Morrison-Porter, Natalie S Haddad, Joel Andrews, Danielle Roberts, Sagar Lonial, Ignacio Sanz and 1 more

Abstract readPreprint
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Doan C NguyenDivision of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine, Emory University, Atlanta, GA, United States.ORCID 0000-0002-5389-6731
Ian T HentenaarDivision of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine, Emory University, Atlanta, GA, United States.
Monica Cabrera-MoraDivision of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine, Emory University, Atlanta, GA, United States.
Shuya KyuDivision of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine, Emory University, Atlanta, GA, United States.
Andrea Morrison-PorterDivision of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine, Emory University, Atlanta, GA, United States.
Natalie S HaddadDivision of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine, Emory University, Atlanta, GA, United States.
Joel AndrewsDepartment of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA, United States.
Danielle RobertsDepartment of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA, United States.
Sagar LonialDepartment of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA, United States.
Ignacio SanzDivision of Rheumatology, Department of Medicine, Emory University, Atlanta, GA, United States.ORCID 0000-0003-4182-587X
F Eun-Hyung LeeDivision of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine, Emory University, Atlanta, GA, United States.ORCID 0000-0002-6133-5942

Funding

Regulation of B cell Responses in SLE and Other Autoimmune DiseasesU19AI110483 · NIAID · EMORY UNIVERSITY · PI Ignacio E. Sanz · 2014 to 2026
$76.6M
Regulation of Pathogenic Plasma Cells in Human SLEP01AI125180 · NIAID · EMORY UNIVERSITY · PI Ignacio E. Sanz · 2016 to 2026
$28.2M
Project-004U54CA260563 · NCI · EMORY UNIVERSITY · PI DHODAPKAR, MADHAV V, SANZ, IGNACIO E. · 2020 to 2024
$10.2M
Molecular Mechanisms of Human Long-lived Plasma Cell Generation in the Bone Marrow and SpleenU01AI141993 · NIAID · EMORY UNIVERSITY · PI Frances Eun-Hyung Lee · 2019 to 2026
$5.7M
Human Plasma Cell Maturation & Maintenance through CD138, TNFRSF, and Modulation of Ig SecretionR01AI172254 · NIAID · EMORY UNIVERSITY · PI Frances Eun-Hyung Lee · 2023 to 2026
$3.1M
Understanding Survival of Human Bone Marrow Long-Lived Plasma CellsR01AI121252 · NIAID · EMORY UNIVERSITY · PI LEE, FRANCES EUN-HYUNG · 2016 to 2020
$2.7M
Gates Foundation INV-002351NCI NIH HHS U54 CA260563NIAID NIH HHS P01 AI125180NIAID NIH HHS R01 AI121252NIAID NIH HHS R01 AI172254NIAID NIH HHS U01 AI141993NIAID NIH HHS U19 AI110483
6 · The paper itself

Abstract

Plasma cells are known antibody-secreting factories with immunoglobulin (Ig) transcripts that increase as the cell matures into a long-lived plasma cell (LLPC) in the bone marrow (BM). Whether the Ig secretion rates among human antibody-secreting cells (ASC) are homogeneous or BM LLPC are capable of secreting more antibodies per cell compared to early-minted blood ASC remain unclear. Here, we use bulk and single cell cultures in a novel

Identifiers

PMID40678229
PMCPMC12270214

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.