ArticleBasic and clinical neuroscience2025
The Predictive Role of Quantitative Electroencephalography in Evaluation of Responsiveness of Obsessive-compulsive Disorder Patients to Fluvoxamine.
Article in Basic and clinical neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: It is not surprising that an obsessive-compulsive disorder (OCD) patient does not respond desirably to the first choice of medication, and it may last up to one year to find the best treatment. According to the consequences of failed antidepressant therapy for OCD, any factor that can predict responsiveness would be of high importance. We investigated the potential predictive value of quantitative electroencephalography (QEEG) in the responsiveness of OCD patients to fluvoxamine. Methods: We included 40 medication-free, non-depressed OCD patients assessed before the intervention and 6 weeks after that. Five minutes of opened eyes and closed eyes QEEG records were taken. The relative power of each frequency band was calculated for all electrodes. The patients received fluvoxamine, 150-300 mg per day. We used univariate analyses and multivariate logistic regression to compare the brain waves between responders and non-responders. Results: Responsiveness was correlated with normal relative powers in FP Conclusion: The electroencephalographic waves of the medial-frontal area and occipital areas can be biomarkers to predict responsiveness to treatment with fluvoxamine.
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