Evidence map›Paper›PMID 40678087›Full record

ArticleBrain & spine2025

The role of Lobectomy in Glioblastoma management: A Retrospective series.

Christina K Arvaniti, Alexandros G Brotis, Jacob S Young, Sivani Sivanrupan, Gracia Menna, Masahiro Nishide, Philippe Schucht, Mitchel Berger, Kostas N Fountas

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Article in Brain & spine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07162324 (Prognostic Factors, Surgical Management and Survival of Glioblastoma Patients), which is not on this map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07162324 not yet recruitingnot on this map

Prognostic Factors, Surgical Management and Survival of Glioblastoma Patients: a Multicenter Prospective Study

TypeobservationalSponsorLarissa University HospitalRan2025 to 2030Enrolled100ConditionsGlioblastoma
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

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4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

9 authors.

Christina K ArvanitiDepartment of Neurosurgery, University Hospital of Larissa, Larissa, 41110, Greece.
Alexandros G BrotisDepartment of Neurosurgery, University Hospital of Larissa, Larissa, 41110, Greece.
Jacob S YoungDepartment of Neurological Surgery, University of San Fransisco, San Fransisco, California, USA.
Sivani SivanrupanDepartment of Neurosurgery, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Gracia MennaDepartment of Neurological Surgery, University of San Fransisco, San Fransisco, California, USA.
Masahiro NishideDepartment of Neurological Surgery, University of San Fransisco, San Fransisco, California, USA.
Philippe SchuchtDepartment of Neurosurgery, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Mitchel BergerDepartment of Neurological Surgery, University of San Fransisco, San Fransisco, California, USA.
Kostas N FountasDepartment of Neurosurgery, University Hospital of Larissa, Larissa, 41110, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Treatment choices for glioblastoma (GB) remain scarce. Multiple clinical studies have demonstrated the importance of supramaximal resection. Recently, it is emphasized the efficacy of lobectomy as treatment option in GB patients, achieving the maximum overall survival (OS) and progression free survival (PFS). Research question: The primary aim of this study is to assess the OS and PFS of GB patients undergoing lobectomy, compared to those undergoing lesionectomy. Secondary aims include the identification of potential survival modifiers among clinical parameters. Materials and methods: This retrospective analysis consists of a multicenter case series of GB patients who underwent lobectomy or lesionectomy between January 2015 and December 2022. Primary outcome included OS and PFS. Identification of potential survival modifiers and postoperative complications were also recorded. Kaplan-Meier survival curves were generated to assess overall survival. Multivariate analyses were performed to identify factors associated with survival. Results: This study included 43 patients. There were 29 cases of lobectomy and 14 cases of lesionectomy. The median OS in lobectomy group was 34 months, compared to 15 months in the lesionectomy group. Multivariate regression analysis indicated that advanced age, tumor location, neurological deficits and the performance of lesionectomy were associated with poorer survival outcomes. Discussion and conclusions: Lobectomy in GB cases is associated with increased OS, compared to lesionectomy. In our series, we demonstrated a significantly better survival with lobectomy than lesionectomy. However, there are complications associated with lobectomy. The identification of the subgroup of patients who would benefit from a lobectomy needs to be addressed.

Indexed as

GlioblastomaLobectomyOverall survivalProgression-free survivalRetrospective

Identifiers

PMID40678087
PMCPMC12269866

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