Evidence map›Paper›PMID 40678081›Full record

ArticleJournal of biomedical optics2025

Anthropomorphic tissue-mimicking phantoms for oximetry validation in multispectral optical imaging.

Kris K Dreher, Janek Gröhl, Friso Grace, Leonardo Ayala, Jan-Hinrich Nölke, Christoph J Bender, Melissa J Watt, Katie-Lou White, Ran Tao, Wibke Johnen and 4 more

Abstract read
In one paragraph

Article in Journal of biomedical optics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Kris K DreherGerman Cancer Research Center (DKFZ), Division of Intelligent Medical Systems (IMSY), Heidelberg, Germany.ORCID 0000-0002-9179-9414
Janek GröhlUniversity of Cambridge, CRUK Cambridge Institute, Cambridge, United Kingdom.ORCID 0000-0002-5332-4856
Friso GraceGerman Cancer Research Center (DKFZ), Division of Intelligent Medical Systems (IMSY), Heidelberg, Germany.ORCID 0009-0004-5550-3518
Leonardo AyalaGerman Cancer Research Center (DKFZ), Division of Intelligent Medical Systems (IMSY), Heidelberg, Germany.ORCID 0000-0002-3574-2085
Jan-Hinrich NölkeGerman Cancer Research Center (DKFZ), Division of Intelligent Medical Systems (IMSY), Heidelberg, Germany.ORCID 0000-0001-7600-3839
Christoph J BenderGerman Cancer Research Center (DKFZ), Division of Intelligent Medical Systems (IMSY), Heidelberg, Germany.ORCID 0009-0009-5432-774X
Melissa J WattUniversity of Cambridge, CRUK Cambridge Institute, Cambridge, United Kingdom.ORCID 0009-0001-7943-2484
Katie-Lou WhiteUniversity of Cambridge, CRUK Cambridge Institute, Cambridge, United Kingdom.
Ran TaoUniversity of Cambridge, CRUK Cambridge Institute, Cambridge, United Kingdom.ORCID 0009-0000-1217-1219
Wibke JohnenDKFZ, Division of Medical Physics in Radiation Oncology, Heidelberg, Germany.
Minu D TizabiGerman Cancer Research Center (DKFZ), Division of Intelligent Medical Systems (IMSY), Heidelberg, Germany.
Alexander SeitelGerman Cancer Research Center (DKFZ), Division of Intelligent Medical Systems (IMSY), Heidelberg, Germany.ORCID 0000-0002-5919-9646
Lena Maier-HeinGerman Cancer Research Center (DKFZ), Division of Intelligent Medical Systems (IMSY), Heidelberg, Germany.ORCID 0000-0003-4910-9368
Sarah E BohndiekUniversity of Cambridge, CRUK Cambridge Institute, Cambridge, United Kingdom.ORCID 0000-0003-0371-8635

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Significance: Optical imaging of blood oxygenation ( Aim: To enable quantitative testing of multispectral imaging methods for assessment of Approach: We used the stable copolymer-in-oil base material to create physical anthropomorphic structures and optimized dyes to mimic the optical absorption of blood across a wide spectral range. Using 3D-printed phantom molds generated from a magnetic resonance image of a human forearm, we molded the material into an anthropomorphic shape. Using both reflectance hyperspectral imaging (HSI) and photoacoustic tomography (PAT), we acquired images of the forearm phantoms and evaluated the performance of linear spectral unmixing (LSU). Results: Based on 10 fabricated forearm phantoms with vessel-like structures featuring five distinct Conclusions: Our anthropomorphic tissue-mimicking phantoms hold potential to provide a robust tool for developing, standardising, and validating optical imaging of

Indexed as

Optical ImagingOximetryPhantoms, ImagingForearmHemoglobinsHumansMagnetic Resonance ImagingOxygenPhotoacoustic TechniquesHemoglobinsOxygenanthropomorphic phantomshyperspectral imagingoptical imagingoximetryphotoacoustic imaging

Identifiers

PMID40678081
PMCPMC12267859

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.