Evidence map›Paper›PMID 40677997›Full record

ArticleNeurotrauma reports2025

Progressive Remote Axonal Degeneration Following Spinal Cord Injury: A Histological and MRI Study.

Gergely David, Alice Motovylyak, Felix Schlegel, Zsofia Kovacs, Christian Kündig, Angela R Filous, Jan M Schwab, Matthew D Budde, Jan Klohs, Patrick Freund

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurotrauma reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Gergely DavidSpinal Cord Injury Center, Balgrist University Hospital, University of Zurich, Zurich, Switzerland.
Alice MotovylyakDepartment of Biomedical Engineering, Marquette University and Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Felix SchlegelInstitute for Biomedical Engineering, University of Zurich and ETH Zurich, Zurich, Switzerland.
Zsofia KovacsInstitute for Biomedical Engineering, University of Zurich and ETH Zurich, Zurich, Switzerland.
Christian KündigSpinal Cord Injury Center, Balgrist University Hospital, University of Zurich, Zurich, Switzerland.
Angela R FilousBelford Center for Spinal Cord Injury, The Ohio State University, Columbus, Ohio, USA.
Jan M SchwabBelford Center for Spinal Cord Injury, The Ohio State University, Columbus, Ohio, USA.
Matthew D BuddeDepartment of Neurosurgery, Clement J Zablocki Veterans Affairs Medical Center, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Jan KlohsInstitute for Biomedical Engineering, University of Zurich and ETH Zurich, Zurich, Switzerland.
Patrick FreundSpinal Cord Injury Center, Balgrist University Hospital, University of Zurich, Zurich, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In acute human spinal cord injury (SCI), magnetic resonance imaging (MRI) reveals progressive neuroanatomical changes at the lesion site and in remote regions. Here, we aimed to elucidate the structural underpinnings of these neuroanatomical changes and to characterize their spatiotemporal distribution in a rat contusion SCI model, using both histology and MRI. First, rats subjected to a thoracic contusion SCI (T8) and sham-operated rats were sacrificed at 56 days post-injury (dpi), and SMI-32 immunohistochemistry was used to assess remote axonal degeneration at cervical segments C2-C5. Second, to evaluate the effect of severity and time since injury on axonal degeneration, rats of varying injury severity were sacrificed at 2, 30, and 90 dpi, respectively, followed by SMI-32 immunohistochemistry. Third,

Indexed as

atrophyaxonal degenerationdiffusion tensor imagingimmunohistochemistryremote degenerationtraumatic spinal cord injury

Identifiers

PMID40677997
PMCPMC12270540

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.