Evidence map›Paper›PMID 40677888›Full record

ArticleRadiology case reports2025

Spontaneous splenic rupture in a patient with factor XIII deficiency: A case report.

José M Zepeda Torres, Essaú Brambila López, Laura B Alegría López, Isac I Ramírez Preciado, Derek G Cantú Ochoa, Heriberto González Canal, Héctor A Benítez Jauregui, Maria H García Ramírez, Daniel A Ángel Montoya, Carolina Topete Rodríguez

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Article in Radiology case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

José M Zepeda TorresGeneral Surgery, High Specialty Medical Unit, Specialty Hospital, National Western Medical Center, Mexican Social Security Institute, Guadalajara, Mexico.
Essaú Brambila LópezGeneral Surgery, High Specialty Medical Unit, Specialty Hospital, National Western Medical Center, Mexican Social Security Institute, Guadalajara, Mexico.
Laura B Alegría LópezGeneral Surgery, High Specialty Medical Unit, Specialty Hospital, National Western Medical Center, Mexican Social Security Institute, Guadalajara, Mexico.
Isac I Ramírez PreciadoGeneral Surgery, High Specialty Medical Unit, Specialty Hospital, National Western Medical Center, Mexican Social Security Institute, Guadalajara, Mexico.
Derek G Cantú OchoaGeneral Surgery, High Specialty Medical Unit, Specialty Hospital, National Western Medical Center, Mexican Social Security Institute, Guadalajara, Mexico.
Heriberto González CanalGeneral Surgery, High Specialty Medical Unit, Specialty Hospital, National Western Medical Center, Mexican Social Security Institute, Guadalajara, Mexico.
Héctor A Benítez JaureguiGeneral Surgery, High Specialty Medical Unit, Specialty Hospital, National Western Medical Center, Mexican Social Security Institute, Guadalajara, Mexico.
Maria H García RamírezGeneral Surgery, High Specialty Medical Unit, Specialty Hospital, National Western Medical Center, Mexican Social Security Institute, Guadalajara, Mexico.
Daniel A Ángel MontoyaGeneral Surgery, High Specialty Medical Unit, Specialty Hospital, National Western Medical Center, Mexican Social Security Institute, Guadalajara, Mexico.
Carolina Topete RodríguezGeneral Surgery, High Specialty Medical Unit, Specialty Hospital, National Western Medical Center, Mexican Social Security Institute, Guadalajara, Mexico.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spontaneous splenic rupture is a rare, life-threatening event, infrequently associated with congenital factor XIII deficiency, a rare coagulation disorder. We present a case of an 18-year-old female with known factor XIII deficiency who presented with acute abdominal pain and was diagnosed with spontaneous splenic rupture. The patient underwent splenectomy due to hemodynamic instability and massive hemorrhage. Postoperative management included factor XIII replacement and standard postsplenectomy prophylaxis. Spontaneous splenic rupture in the setting of factor XIII deficiency is exceedingly rare, with only a limited number of cases reported in the literature. This case highlights the importance of considering coagulation disorders in the differential diagnosis of atraumatic splenic rupture. Prompt diagnosis and multidisciplinary management, including surgical intervention when necessary, are critical for optimizing patient outcomes. This case underscores that factor XIII deficiency can lead to spontaneous life-threatening hemorrhage. Clinicians should maintain a high index of suspicion for this pathology in patients with known coagulopathies, and timely intervention is essential to improve patient outcomes. The importance of this approach is to quickly treat it when needed because is very deadly.

Indexed as

Coagulation disorderFactor XIII deficiencySpontaneous splenic rupture

Identifiers

PMID40677888
PMCPMC12269485

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