ArticleBiomedical optics express2025
Integrated visible-light optical coherence tomography and fluorescence scanning laser ophthalmoscopy to image retinal ganglion cell axons.
Article in Biomedical optics express, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- 100-degree Non-Contact Retinal Imaging in Mice Using a Multimodal Vis-OCT and SLO System.IEEE photonics technology letters : a publication of the IEEE Laser and Electro-optics Society · 2026Article
- Ultrabroadband OCT for simultaneous visible and near-infrared light imaging of the mouse retina.Biomedical optics express · 2026Article
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Authors and funding
8 authors.
Funding
Abstract
Retinal ganglion cell (RGC) soma and axonal damage is a hallmark of optic neuropathies. Visible-light OCT fibergraphy (vis-OCTF) enables non-invasive imaging and quantitative assessment of individual RGC axon bundles; however, validating vis-OCTF using confocal fluorescence imaging of flat-mounted postmortem retina is less accurate due to structural alterations caused by flat-mount preparation and cannot be performed longitudinally. For in vivo vis-OCTF validation, we developed an integrated visible-light optical coherence tomography (vis-OCT) and fluorescence scanning laser ophthalmoscopy (SLO) system. The vis-OCT had a 100 nm bandwidth with a center wavelength of 560 nm, offering an axial resolution of 1.3 µm in the retina. The lateral resolutions of vis-OCT and SLO were 4 µm and 3.5 µm, respectively. In the transgenic Eno2-YFP mice, we showed that vis-OCTF and SLO provide consistent RGC axon bundle imaging results. Measuring 30 axon bundle widths from six mice yielded a Pearson correlation coefficient of 0.991 between SLO and vis-OCTF. Thus, the combined SLO and vis-OCT can potentially achieve multimodal longitudinal in vivo studies of RGC pathologies.
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Registered trials
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