Evidence map›Paper›PMID 40677819›Full record

ArticleBiomedical optics express2025

Telecentric model eye for correction of image distortion in adaptive optics ophthalmoscopes.

Vyas Akondi, Gastón A Ayubi, Xiaojing Huang, Karteek Kunala, Alfredo Dubra

Abstract read
In one paragraph

Article in Biomedical optics express, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Vyas AkondiDept. of Physical Sciences, Indian Institute of Science Education and Research (IISER), Berhampur, Odisha 760010, India.ORCID https://orcid.org/0000-0002-3987-2776
Gastón A AyubiByers Eye Institute, Stanford University, Palo Alto, California 94303, USA.ORCID https://orcid.org/0000-0002-7790-1793
Xiaojing HuangByers Eye Institute, Stanford University, Palo Alto, California 94303, USA.ORCID https://orcid.org/0000-0001-5150-985X
Karteek KunalaByers Eye Institute, Stanford University, Palo Alto, California 94303, USA.ORCID https://orcid.org/0000-0002-5245-0850
Alfredo DubraByers Eye Institute, Stanford University, Palo Alto, California 94303, USA.ORCID https://orcid.org/0000-0002-6506-9020

Funding

Stanford Vision Research CoreP30EY026877 · NEI · STANFORD UNIVERSITY · PI Jeffrey L Goldberg · 2017 to 2026
$8.0M
Increasing the isoplanatic patch in adaptive optics ophthalmoscopyR01EY032147 · NEI · STANFORD UNIVERSITY · PI DUBRA, ALFREDO · 2021 to 2025
$2.4M
Improving rigor and reproducibility in adaptive optics ophthalmoscopyR01EY031360 · NEI · STANFORD UNIVERSITY · PI DUBRA, ALFREDO · 2020 to 2023
$2.3M
Low Latency Eye-Motion CompensationR01EY032669 · NEI · STANFORD UNIVERSITY · PI DUBRA, ALFREDO · 2021 to 2024
$1.8M
NEI NIH HHS P30 EY026877NEI NIH HHS R01 EY031360NEI NIH HHS R01 EY032147NEI NIH HHS R01 EY032669
6 · The paper itself

Abstract

Here, we demonstrate a telecentric model eye for measuring scanning, sampling, and optical distortion in AO ophthalmoscopes across a 10-diopter focus range, seeking to improve the reproducibility of adaptive optics (AO) ophthalmoscopy biomarkers. The model eye lens provides diffraction-limited performance when imaging with 800 nm light over circular 2.0, 3.0, 4.6, and 9.2° fields of view through 8, 6, 4, and 2 mm diameter aperture stops, respectively. Measurements of double-pass wavefront aberrations using both model and real retinas show that the use of opal glass model retinas, rough model retina surfaces, and wavefront sensing beacon scanning mitigate first-pass aberrations. This is particularly important, as first-pass aberrations are often assumed but not always achieved in AO ophthalmoscopes. Using the model eye with custom distortion estimation algorithms, we recorded 0.06% non-isotropic scaling repeatability, 0.02° shear repeatability, 0.5% reproducibility for both metrics and a root-mean-square residual distortion of 0.1 pixels across the field of view and focus range.

Identifiers

PMID40677819
PMCPMC12265597

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.