ArticleBiomedical optics express2025
Pilot study on photoacoustic imaging and confocal Raman spectroscopy-derived biomarkers for assessing structural and physiological skin changes in atopic dermatitis and metabolic diseases.
Article in Biomedical optics express, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Comparative biomolecular analysis of normal and healed skin tissue from diabetic and non-diabetic rats using Raman spectroscopy.Lasers in medical science · 2026Article
- Introduction to the feature issue Photoacoustic Imaging and Sensing: Beyond Fundamentals to Translation.Biomedical optics express · 2026Article
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Authors and funding
9 authors.
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Abstract
Atopic dermatitis (AD), a chronic inflammatory condition, is closely associated with obesity and type 2 diabetes mellitus (diabetes/DM). For the first time, using high-resolution photoacoustic imaging (PAI) and in-house-developed handheld confocal Raman spectroscopy (CRS), we studied in 35 subjects the dermal microvascular architecture, epidermal biochemical profiles and skin alterations in AD with DM and obesity. Utilizing the imaging-derived markers, we observed pronounced dermal hypervascularization in DM and obesity, worsening with AD, as reflected by altered oxygen saturation and epidermal biochemicals. Our findings highlight the role of non-invasive biophotonics techniques in assessing metabolic dysfunction during AD progression and management, underscoring their potential as promising non-invasive tools for real-time skin assessment.
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