ArticleAACE endocrinology and diabetes
Recurrent Euglycemic Diabetic Ketoacidosis Precipitated by Diabetic Myonecrosis in a Patient with Type 1 Diabetes Mellitus.
Article in AACE endocrinology and diabetes. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background/Objective: Euglycemic diabetic ketoacidosis (eDKA) is a well-recognized complication with sodium linked cotransport of glucose-2 inhibitor (SGLT2i) use. Recurrent eDKA is an infrequently described entity. We describe a patient with recurrent eDKA precipitated by diabetic myonecrosis. Case Report: A 48-year-old male with Diabetes Mellitus treated with empagliflozin and insulin, presented with left thigh pain and anorexia. Physical examination was notable for BMI 16 kg/m Discussion: The risk of eDKA with SGLT2i use is increased in patients with T1DM with decreased oral intake, surgery or trauma. Although the half-life of empagliflozin is 12 to 14 hours, persistent euglycemic DKA for 7 to 12 days from the last dose has been reported. Persistent glucosuria and ketonuria in this patient with serum glucose below the renal threshold confirmed recurrent eDKA. Conclusion: eDKA may recur until 2 weeks from last dose of SGLT2i under certain conditions.
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