ArticleAACE endocrinology and diabetes
Unexplained Bilateral Adrenal Hemorrhage and Adrenal Insufficiency Unveiling Burkitt's Lymphoma.
Article in AACE endocrinology and diabetes. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background/Objective: Adrenal hemorrhage (AH) and adrenal insufficiency (AI) are rare, life-threatening conditions, typically linked to trauma, sepsis, or anticoagulation. Burkitt's lymphoma (BL), an aggressive B-cell non-Hodgkin lymphoma, rarely involves the adrenal glands and has not been reported to present with AH and AI. This report describes a unique case of AH and AI presenting as manifestations of BL, highlighting the importance of considering malignancy in unexplained AH and AI. Case Report: A 16-year-old boy presented with acute right flank pain and muscle spasms. Imaging revealed a right suprarenal hematoma with active contrast extravasation, managed with adrenal artery embolization. Two weeks later, he developed recurrent abdominal pain, vomiting, and distention. Computed tomography showed bilateral adrenal enlargement with necrosis and hemorrhage. Laboratory test results revealed normocytic anemia, increased lactate dehydrogenase level, and hypoglycemia. AI was confirmed (serum cortisol level, 1.5 μg/dL; adrenocorticotropic hormone level, 82 pg/mL), prompting hydrocortisone replacement. Positron emission tomography/computed tomography revealed hypermetabolic lesions in bilateral adrenal glands, lymph nodes, pleura, peritoneum, and bone marrow. Neck lymph node biopsy confirmed BL, showing a "starry sky" pattern, CD20 positivity, and Ki-67 nearing 100%. Intensive chemotherapy led to significant clinical improvement. Discussion: This case highlights the diagnostic challenge of AH and AI without typical risk factors. BL, although rarely involving the adrenal glands, should be considered in unexplained AH. Conclusion: This report highlights the importance of considering malignancy in unexplained AH and AI, even without conventional risk factors.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.