Evidence map›Paper›PMID 40677774›Full record

ArticleCanadian liver journal2024

Breaking boundaries: Unraveling metabolic dysfunction-associated steatotic liver disease in children of India and Canada.

Vikrant Sood, Bikrant B Lal, Aniket Deshmukh, Rajeev Khanna, Esha Gahunia, Jamie Strain, Carolina Jimenez Rivera, Seema Alam, Mohit Kehar

Abstract read
In one paragraph

Article in Canadian liver journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Commentary on Kehar et al.Canadian liver journal · 2025
    Article
  3. Response to Commentary on Kehar et al.Canadian liver journal · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Vikrant SoodDepartment of Pediatric Hepatology, Institute of Liver and Biliary Sciences, Vasant Kunj, New Delhi, India.
Bikrant B LalDepartment of Pediatric Hepatology, Institute of Liver and Biliary Sciences, Vasant Kunj, New Delhi, India.
Aniket DeshmukhDepartment of Pediatric Hepatology, Institute of Liver and Biliary Sciences, Vasant Kunj, New Delhi, India.
Rajeev KhannaDepartment of Pediatric Hepatology, Institute of Liver and Biliary Sciences, Vasant Kunj, New Delhi, India.
Esha GahuniaDivision of Pediatric Gastroenterology, Hepatology and Nutrition, Children's Hospital of Eastern Ontario, Department of Pediatrics, University of Ottawa, Ottawa, Canada.
Jamie StrainDivision of Pediatric Gastroenterology, Hepatology and Nutrition, Children's Hospital of Eastern Ontario, Department of Pediatrics, University of Ottawa, Ottawa, Canada.
Carolina Jimenez RiveraDivision of Pediatric Gastroenterology, Hepatology and Nutrition, Children's Hospital of Eastern Ontario, Department of Pediatrics, University of Ottawa, Ottawa, Canada.
Seema AlamDepartment of Pediatric Hepatology, Institute of Liver and Biliary Sciences, Vasant Kunj, New Delhi, India.
Mohit KeharDivision of Pediatric Gastroenterology, Hepatology and Nutrition, Children's Hospital of Eastern Ontario, Department of Pediatrics, University of Ottawa, Ottawa, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Non-alcoholic fatty liver disease (NAFLD) or metabolic dysfunction-associated steatotic liver disease (MASLD) is a major cause of chronic liver disease in children. Its prevalence is rising globally, yet it is uncertain if its onset and severity vary between countries. We aimed to compare pediatric NAFLD in two Canadian and Indian tertiary care centers. Methods: This study was conducted as a retrospective cohort study and patient related details were retrieved from the electronic records and reviewed. Results: The study analyzed a total of 184 children with NAFLD/MASLD (94 from the Indian site and 89 from the Canadian site) with concordance between NAFLD and MASLD definitions. The Indian children had a higher proportion of symptomatic presentations and family history of metabolic disorders ( Conclusions: The study found significant differences between cohorts. Canadian children showed higher obesity grades and greater hepatic steatosis and fibrosis severity. To comprehend the underlying causes, future studies are imperative.

Indexed as

Canadian childrencontrolled attenuation parameterIndian childrenliver stiffnesspediatric metabolic dysfunction-associated steatotic liver disease (MASLD)pediatric non-alcoholic fatty liver disease (NAFLD)transient elastography

Identifiers

PMID40677774
PMCPMC12269244

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.