Evidence map›Paper›PMID 40677770›Full record

ArticleCanadian liver journal2024

Evolving trends in liver transplantation eligibility: A shift toward inclusivity for older adults at a Canadian Transplant Center.

Gabrielle Jutras, Genevieve Huard, Marc Bilodeau, Julien Bissonnette, Helene Castel, Jeanne-Marie Giard, Julian Hercun, Catherine Vincent, Bernard Willems, Philippe Willems and 1 more

Abstract read
In one paragraph

Article in Canadian liver journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Gabrielle JutrasDepartment of Hepatology, Division of Medicine, Centre Hospitalier de l'Université de Montréal, Montréal, Quebec, Canada.
Genevieve HuardDepartment of Hepatology, Division of Medicine, Centre Hospitalier de l'Université de Montréal, Montréal, Quebec, Canada.
Marc BilodeauDepartment of Hepatology, Division of Medicine, Centre Hospitalier de l'Université de Montréal, Montréal, Quebec, Canada.
Julien BissonnetteDepartment of Hepatology, Division of Medicine, Centre Hospitalier de l'Université de Montréal, Montréal, Quebec, Canada.
Helene CastelDepartment of Hepatology, Division of Medicine, Centre Hospitalier de l'Université de Montréal, Montréal, Quebec, Canada.
Jeanne-Marie GiardDepartment of Hepatology, Division of Medicine, Centre Hospitalier de l'Université de Montréal, Montréal, Quebec, Canada.
Julian HercunDepartment of Hepatology, Division of Medicine, Centre Hospitalier de l'Université de Montréal, Montréal, Quebec, Canada.
Catherine VincentDepartment of Hepatology, Division of Medicine, Centre Hospitalier de l'Université de Montréal, Montréal, Quebec, Canada.
Bernard WillemsDepartment of Hepatology, Division of Medicine, Centre Hospitalier de l'Université de Montréal, Montréal, Quebec, Canada.
Philippe WillemsDepartment of Hepatology, Division of Medicine, Centre Hospitalier de l'Université de Montréal, Montréal, Quebec, Canada.
Jennifer C LaiDivision of Gastroenterology and Hepatology, Department of Medicine, University of California - San Francisco, San Francisco, California, United States.

Funding

UCSF Liver Core CenterP30DK026743 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Jennifer Y. Chen · 1986 to 2026
$30.7M
NIDDK NIH HHS P30 DK026743
6 · The paper itself

Abstract

Background: The surge of end-stage liver disease among older individuals challenges traditional age-based criteria for liver transplantation (LT), historically capped at 65 years. Our Canadian center shifted away from using chronologic age as an absolute refusal criterion since 2019, enabling those aged 65 years and older to seek LT. This study aimed to investigate temporal trends in the transplant care cascade for patients aged 65 and older at our center, pre- and post-clinical shift. Methods: A retrospective study in a single Canadian transplant center reviewed LT referrals between 2015 and 2023, analyzing proportions of patients aged 65 and above at each stage. Specific intervals, 2015-2018 and 2019-2023, were defined for pre- and post-comparisons. Results: Among the 1,007 LT referrals, 11% (n = 110) were patients aged ≥65 years, with 74% ( Conclusions: Removing the age cap increased older patient engagement in the LT care cascade. This emphasizes the crucial role of actively promoting awareness of evolving LT eligibility criteria. Concerted efforts should focus on improving transplantation accessibility in older patients, ensuring age alone does not impede the process.

Indexed as

ageliver transplantliver transplant eligibilityolder patients

Identifiers

PMID40677770
PMCPMC12269203

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.