ArticleBioactive materials2025
Mitochondrial uptake and translocation by macrophages promotes vascular regeneration in peripheral ischemia.
Article in Bioactive materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Mitochondria-Targeted Nanotherapeutics: A Promising Strategy in Modulating Mitochondrial Function, Transfer, and Transplantation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Plasma-derived mitochondria as a minimal manipulation alternative for attenuating inflammatory immune responses.Regenerative biomaterials · 2026Article
- Plasma-derived mitochondrial transplantation attenuates paraspinal muscle atrophy following spinal surgery.Regenerative biomaterials · 2025Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mitochondrial transplantation promotes cardiac repair following injury; however, its effects on limb ischemia due to peripheral artery disease (PAD) remain unclear. In this study, transplantation with mitochondria isolated from both murine muscle tissue and human arterial blood significantly promotes revascularization and blood flow recovery in a hindlimb ischemia mouse model. Our findings further show that transplanted mitochondria promote macrophages infiltrating into ischemic regions. Additionally, internalization of the mitochondria promotes macrophage M2-like polarization, resulting in increased pro-angiogenic factors expression and secretion and subsequent endothelial cell and smooth muscle cell proliferation. In conclusion, mitochondrial transplantation shows considerable potential in improving peripheral ischemia and provides therapeutic options for patients with PAD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.