Evidence map›Paper›PMID 40677753›Full record

ArticleImaging neuroscience (Cambridge, Mass.)2024

Age- and sex-related differences in human α4β2* nicotinic acetylcholine receptor binding evaluated with [

Andrew McVea, Jihoon Choi, Alexandra DiFilippo, Max McLachlan, Brecca Bettcher, Matthew Zammit, Charles K Stone, Dana Tudorascu, Jogeshwar Mukherjee, Bradley T Christian

Abstract read
In one paragraph

Article in Imaging neuroscience (Cambridge, Mass.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Increased Binding of [Synapse (New York, N.Y.) · 2026
    Article
  2. [Synapse (New York, N.Y.) · 2025
    Article
  3. Reduction in [Brain research · 2025
    Article
  4. Evaluation of [Receptors (Basel, Switzerland) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Andrew McVeaDepartment of Medical Physics, University of Wisconsin - Madison School of Public Health, Madison, WI, United States.
Jihoon ChoiWaisman Laboratory for Brain Imaging and Behavior, University of Wisconsin - Madison School of Public Health, Madison, WI, United States.
Alexandra DiFilippoDepartment of Medical Physics, University of Wisconsin - Madison School of Public Health, Madison, WI, United States.
Max McLachlanDepartment of Medical Physics, University of Wisconsin - Madison School of Public Health, Madison, WI, United States.
Brecca BettcherDepartment of Medical Physics, University of Wisconsin - Madison School of Public Health, Madison, WI, United States.
Matthew ZammitWaisman Laboratory for Brain Imaging and Behavior, University of Wisconsin - Madison School of Public Health, Madison, WI, United States.
Charles K StoneWisconsin Alzheimer's Disease Research Center, University of Wisconsin - Madison School of Medicine and Public Health, Madison, WI, United States.
Dana TudorascuDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, United States.
Jogeshwar MukherjeeDepartment of Radiological Sciences, University of California - Irvine School of Medicine, Orange, CA, United States.
Bradley T ChristianDepartment of Medical Physics, University of Wisconsin - Madison School of Public Health, Madison, WI, United States.

Funding

Waisman Center Intellectual and Developmental Disabilities Research CenterP50HD105353 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI Qiang Chang · 2021 to 2026
$8.5M
PET Imaging agents for a4b2 Nicotinic ReceptorsRF1AG029479 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI CHRISTIAN, BRADLEY T, MUKHERJEE, JOGESHWAR · 2019 to 2020
$2.2M
Biograph Horizon PET/CTS10OD025245 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI CHRISTIAN, BRADLEY T · 2018 to 2018
$1.3M
NIA NIH HHS RF1 AG029479NICHD NIH HHS P50 HD105353NIH HHS S10 OD025245
6 · The paper itself

Abstract

Neuronal α4β2* nicotinic acetylcholine receptors (nAChRs) are stimulated by nicotine and are associated with tobacco dependence. [

Indexed as

distribution volume ratio (DVR)nAChR imagingPET imagingreference regionthalamic nuclei

Identifiers

PMID40677753
PMCPMC12269774

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.