ArticleBrain communications2025
Beta burst-driven adaptive deep brain stimulation for gait impairment and freezing of gait in Parkinson's disease.
Article in Brain communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effects of different types of deep brain stimulation on gait disorders in patients with Parkinson's disease: a network meta-analysis of randomized controlled trials.Frontiers in aging neuroscience · 2025Pooled it
- Inconsistent subthalamic local field potential beta activity amid in- and antiphasic neuronal bursts.NPJ Parkinson's disease · 2026Article
- Activity-dependent adaptive deep brain stimulation improves gait in Parkinson's disease.Nature medicine · 2026Article
- Dopamine and the dynamics of subthalamic and leg muscle activities in parkinsonian stepping.Brain : a journal of neurology · 2026Article
- Adaptive Deep Brain Stimulation for Parkinson's Disease: Navigating the Roadblocks to Clinical Implementation.Movement disorders : official journal of the Movement Disorder Society · 2026Review
- Brain-Computer Interfaces: The Dawn of a New Era in Disease Treatment.Exploration (Beijing, China) · 2026Review
- N2G calibrator: a cross-subject adversarial learning framework for neural signal-driven gait tracking in Parkinson's disease.Communications engineering · 2026Article
- Multitarget brain implants enable generalized decoding of Parkinson's disease symptoms from chronic home recordings.Research square · 2026Article
- Scalable biomarkers of Parkinson's disease: insights from mobile EEG in Peru.Scientific reports · 2026Article
- Freezing of Gait in Parkinson's Disease: A Scoping Review on the Path Towards Real-Time Therapies.Sensors (Basel, Switzerland) · 2026Article
- What is new in Freezing of Gait?Journal of neurology · 2026Review
- Real-Time Kinematic Adaptive Deep Brain Stimulation Safely Reduces Gait Impairment and Freezing of Gait in Parkinson's Disease.medRxiv : the preprint server for health sciences · 2026Article
- Local field potential biomarkers for adaptive deep brain stimulation in Parkinson's disease: A scoping review.Surgical neurology international · 2026Review
- Proceedings of the 13th annual deep brain stimulation think tank: the evolving landscape.Frontiers in human neuroscience · 2026Review
- Article
- Real-world chronic recordings from implantable adaptive deep brain stimulation systems for Parkinson's disease motor state classification.Frontiers in bioinformatics · 2026Article
- Low-Frequency Adaptive Deep Brain Stimulation for Parkinson's Disease.medRxiv : the preprint server for health sciences · 2025Article
- Beta Power Response After Levodopa Intake in Parkinson's Disease Patients With Chronic Sensing-Enabled Deep Brain Stimulation.Annals of neurology · 2025Article
- Closing the loop in DBS: A data-driven approach.Parkinsonism & related disorders · 2025Review
- N2GNet tracks gait performance from subthalamic neural signals in Parkinson's disease.Research square · 2024Article
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16 authors.
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Abstract
Freezing of gait is a debilitating symptom of Parkinson's disease that is often refractory to medication. Prolonged beta bursts within the subthalamic nucleus are associated with worse impairment and freezing, which are improved with deep brain stimulation. The goal of the study was to investigate the feasibility, safety and tolerability of beta burst-driven adaptive deep brain stimulation for gait impairment and freezing of gait in Parkinson's disease. Seven individuals with Parkinson's disease were implanted with the investigational Summit™ RC + S deep brain stimulation system (Medtronic, PLC, Dublin, Ireland). A PC-in-the-loop architecture adjusted stimulation in real-time based on beta burst durations in the subthalamic nucleus. A rigorous calibration procedure was employed to find participant-specific adaptive deep brain stimulation parameters. In a double-blind design, participants performed a harnessed stepping-in-place task, a free walking turning and barrier course, instrumented measures of bradykinesia and clinical motor assessments in four conditions: OFF stimulation, on adaptive, continuous or randomly adapting deep brain stimulation. Adaptive deep brain stimulation was successfully implemented and deemed safe and tolerable in all participants. Gait metrics such as overall percent time freezing and mean peak shank angular velocity improved on adaptive deep brain stimulation compared to OFF and showed similar efficacy as continuous deep brain stimulation. Similar improvements were also seen for overall clinical motor impairment, including tremor and quantitative metrics of bradykinesia. The current pilot study demonstrated initial safety, tolerability, and feasibility of adaptive deep brain stimulation for freezing of gait in Parkinson's disease in the acute laboratory setting, supporting the future investigation of its longer-term efficacy in the at-home setting.
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