ArticleBrain communications2025
Vasomotor fluctuations are increased in primary central nervous system lymphoma: a case-control study with fast functional MRI.
Article in Brain communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
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19 authors.
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Abstract
Primary CNS lymphoma is an aggressive brain tumour. An accumulation of malignant cells around cerebral blood vessels may potentially impair the convection of cerebrospinal fluid within perivascular spaces. Recent evidence links an increased variation of the blood oxygen level-dependent signal, a marker for haemodynamic changes, to risk of mortality in lymphoma. In this study, we aimed to characterize the physiological source(s) of increased blood oxygen level-dependent signal variation in lymphoma and characterize the link between altered physiological pulsations and mortality. Thirty lymphoma patients (median age 66 years; 9 females) and 40 healthy age-matched controls (median age 62 years; 29 females) were scanned using an ultrafast functional MRI sequence. We extracted physiological brain pulsation frequency bands from functional MRI data: full band (0.008-5 Hz), very low frequency (0.008-0.1 Hz), respiratory (0.1-0.5 Hz) and cardiac (0.7-2 Hz). We compared the respective pulsation amplitudes between groups using non-parametric covariate-adjusted permutation tests and studied the link between region-specific pulsation amplitudes and mortality in receiver-operating characteristic (ROC) and survival analyses. The lymphoma group showed higher amplitudes in all brain pulsation bands (
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