Evidence map›Paper›PMID 40677699›Full record

ArticleBrain communications2025

Associations between night/shift working and late-life brain health.

Josh King-Robson, Jennifer M Nicholas, Sarah-Naomi James, Ashvini Keshavan, Dylan M Williams, James Groves, Carole H Sudre, Kirsty Lu, Josephine Barnes, William Coath and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Josh King-RobsonDementia Research Centre, UCL Queen Square Institute of Neurology, University College London, London, WC1N 3BG, UK.ORCID https://orcid.org/0000-0002-3662-9404
Jennifer M NicholasDepartment of Medical Statistics, London School of Hygiene & Tropical Medicine, University of London, London WC1E 7HT, UK.
Sarah-Naomi JamesDementia Research Centre, UCL Queen Square Institute of Neurology, University College London, London, WC1N 3BG, UK.ORCID https://orcid.org/0000-0002-3800-4416
Ashvini KeshavanDementia Research Centre, UCL Queen Square Institute of Neurology, University College London, London, WC1N 3BG, UK.
Dylan M WilliamsMRC Unit for Lifelong Health and Ageing at UCL, University College London, London WC1E 7HB, UK.
James GrovesDementia Research Centre, UCL Queen Square Institute of Neurology, University College London, London, WC1N 3BG, UK.
Carole H SudreDementia Research Centre, UCL Queen Square Institute of Neurology, University College London, London, WC1N 3BG, UK.
Kirsty LuDementia Research Centre, UCL Queen Square Institute of Neurology, University College London, London, WC1N 3BG, UK.ORCID https://orcid.org/0000-0002-8416-2183
Josephine BarnesDementia Research Centre, UCL Queen Square Institute of Neurology, University College London, London, WC1N 3BG, UK.
William CoathDementia Research Centre, UCL Queen Square Institute of Neurology, University College London, London, WC1N 3BG, UK.ORCID https://orcid.org/0000-0002-3976-9461
David M CashDementia Research Centre, UCL Queen Square Institute of Neurology, University College London, London, WC1N 3BG, UK.ORCID https://orcid.org/0000-0001-7833-616X
Sarah E KeussDementia Research Centre, UCL Queen Square Institute of Neurology, University College London, London, WC1N 3BG, UK.
Marcus RichardsMRC Unit for Lifelong Health and Ageing at UCL, University College London, London WC1E 7HB, UK.ORCID https://orcid.org/0000-0001-9191-2192
Jason D WarrenDementia Research Centre, UCL Queen Square Institute of Neurology, University College London, London, WC1N 3BG, UK.
Jonathan M SchottDementia Research Centre, UCL Queen Square Institute of Neurology, University College London, London, WC1N 3BG, UK.ORCID https://orcid.org/0000-0003-2059-024X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sleep and circadian disturbances are associated with increased dementia risk. The mechanism remains poorly understood. We aimed to examine the relationship between night/shift working at age 31 and biomarkers of late-life brain health and to estimate the extent to which these relationships are mediated by unhealthy lifestyle behaviours. A prospective longitudinal cohort study, Insight 46, recruited participants from the Medical Research Council National Survey of Health and Development (NSHD) 1946 British Birth cohort. All born in the same week in 1946, participants were assessed at age 70 with multi-modal structural and molecular brain imaging and fluid biomarkers, from which whole-brain and hippocampal volumes, white matter hyper-intensity volume (WMHV),

Indexed as

Alzheimer’s diseasecircadian rhythmsdementiashift worksleep

Identifiers

PMID40677699
PMCPMC12268499

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.