Evidence map›Paper›PMID 40677692›Full record

ReviewJHEP reports : innovation in hepatology2025

Transjugular diagnostic procedures in hepatology: Indications, techniques and interpretation.

Dominik Bettinger, Annalisa Berzigotti, Mattias Mandorfer, Cristina Ripoll, Christian Labenz, Eugen Zizer, Tony Bruns, Andrea De Gottardi, Johannes Emrich, Cornelius Engelmann and 21 more

Abstract readReview
In one paragraph

Review in JHEP reports : innovation in hepatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Changes in SSM Assessed via 100 Hz-VCTE Are Associated With Acute HVPG-Response to i.v. Propranolol: A European Multicentre Study.Liver international : official journal of the International Association for the Study of the Liver · 2026
    Article
  4. Article
  5. Article
  6. Liver failure due to metastatic melanoma: A case report.World journal of clinical cases · 2025
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors.

Dominik BettingerDepartment of Medicine II, Medical Center University of Freiburg, Faculty of Medicine, University of Freiburg, Hugstetter Str. 55, D-79106 Freiburg, Germany.
Annalisa BerzigottiDepartment of Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern, Switzerland.
Mattias MandorferDivision of Gastroenterology and Hepatology, Medical University of Vienna, Vienna, Austria, Vienna Hepatic Hemodynamic Lab, Medical University of Vienna, Vienna, Austria, Department of Medicine III and Clinical Research Group Mechanisms in Portal Hypertension, Medical University of Vienna, Vienna, Austria.
Cristina RipollInternal Medicine IV, Department for Gastroenterology, Hepatology, Interdisciplinary Endoscopy and Infectious Diseases, Jena University Hospital, Friedrich-Schiller University, Jena 07747, Germany.
Christian LabenzDepartment of Internal Medicine, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.
Eugen ZizerKreiskliniken Günzburg-Krumbach, Lindenallee 1, 89312 Günzburg, Germany.
Tony BrunsDepartment of Internal Medicine III, University Hospital RWTH Aachen, Aachen, Germany.
Andrea De GottardiLuzerner Kantonsspital, Lucerne, Switzerland.
Johannes EmrichMedizinische Klinik II, St. Josefs-Hospital, Wiesbaden, Germany.
Cornelius EngelmannMedical Department, Division of Gastroenterology and Hepatology, Campus Virchow-Klinikum, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Benjamin MaasoumyDepartment of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, Hannover, Germany.
Arnulf FerlitschDepartment of Internal Medicine I, St John of God Hospital, Vienna, Austria.
Valentin FuhrmannKlinik für Innere Medizin, Heilig Geist Krankenhaus Köln, Graseggerstraße 105, 50737, Köln, Germany.
Jan HinrichsSt. Bernward Krankenhaus, Klinik für diagnostische und interventionelle Radiologie und Neuroradiologie, Hildesheim, Germany.
Christian JansenDepartment of Internal Medicine I, University Hospital Bonn, Bonn, Germany.
Karoline LacknerDiagnostic and Research Institute of Pathology, Medical University of Graz, 8010, Graz, Austria.
Robert MatzbergerDepartment of Medicine I (Gastroenterology, Hepatology, Diabetology & Nephrology), Klinikum Landshut, Landshut, Germany.
Carsten MeyerDepartment of Radiology, University Hospital, University Bonn, Bonn, Germany.
Behrang MozayaniDepartment of Pathology, Medical University of Vienna, Vienna, Austria.
Michael PraktiknjoDepartment of Medicine B, Gastroenterology, Hepatology, Endocrinology, Infectious Diseases, Universitätsklinikum Münster, Münster, Germany.
Philipp A ReukenInternal Medicine IV, Department for Gastroenterology, Hepatology, Interdisciplinary Endoscopy and Infectious Diseases, Jena University Hospital, Friedrich-Schiller University, Jena 07747, Germany.
Michael SchultheissDepartment of Medicine II, Medical Center University of Freiburg, Faculty of Medicine, University of Freiburg, Hugstetter Str. 55, D-79106 Freiburg, Germany.
Alexander ZipprichInternal Medicine IV, Department for Gastroenterology, Hepatology, Interdisciplinary Endoscopy and Infectious Diseases, Jena University Hospital, Friedrich-Schiller University, Jena 07747, Germany.
Christian M LangeDepartment of Internal Medicine II, LMU University Hospital Munich, Munich, Germany.
Roman KloecknerInstitute for Interventional Radiology, University Hospital Schleswig-Holstein Campus Luebeck, Lübeck, Germany.
Christoph SarrazinMedizinische Klinik II, St. Josefs-Hospital, Wiesbaden, Germany.
Jonel TrebickaDepartment of Medicine B, Gastroenterology, Hepatology, Endocrinology, Infectious Diseases, Universitätsklinikum Münster, Münster, Germany.
Thomas ReibergerDivision of Gastroenterology and Hepatology, Medical University of Vienna, Vienna, Austria, Vienna Hepatic Hemodynamic Lab, Medical University of Vienna, Vienna, Austria, Department of Medicine III and Clinical Research Group Mechanisms in Portal Hypertension, Medical University of Vienna, Vienna, Austria.
Jaume BoschDepartment of Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern, Switzerland.
Matthias M DollingerDepartment of Medicine I (Gastroenterology, Hepatology, Diabetology & Nephrology), Klinikum Landshut, Landshut, Germany.
German (D) – Austrian (A) – Swiss (CH) portal hypertension (DACH-PH) consortium

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Measurement of the hepatic venous pressure gradient (HVPG) and transjugular liver biopsy have emerged as important tools in clinical hepatology. Measurement of HVPG is considered the gold standard for detecting clinically significant portal hypertension, with an HVPG of ≥10 mmHg being the key prognostic threshold in patients with compensated advanced chronic liver disease (cACLD; compensated cirrhosis). A transjugular liver biopsy can be obtained within the same procedure and may be preferred over percutaneous liver biopsy in patients with coagulopathy, ascites and/or significant obesity. Endoscopic ultrasound-guided procedures are currently under investigation and require standardisation. This article summarises critical technical aspects of HVPG measurements and transjugular liver biopsy and provides a detailed overview of their current role in the context of emerging non-invasive tests and endoscopic approaches.

Indexed as

Cirrhosishepatic venous pressure gradientHVPGminimally invasiveportal hypertensionporto-sinusoidal vascular disorderPSVDtransjugular liver biopsy

Identifiers

PMID40677692
PMCPMC12269627

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.