Evidence map›Paper›PMID 40677617›Full record

ArticleRheumatology advances in practice2025

Baseline 25-hydroxyvitamin D levels predict the effects of vitamin D supplementation on joint symptoms and cartilage loss in patients with knee osteoarthritis.

Tian Wang, Shuang Zheng, Xingzhong Jin, Han Cen, Zhaohua Zhu, Weiyu Han, Anita Wluka, Flavia Cicuttini, Peihua Cao, Changhai Ding

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Rheumatology advances in practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01176344 (Does Vitamin D Supplementation Prevent Progression of Knee Osteoarthritis? A Randomised Controlled Trial), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01176344 phase3completednot on this map

Does Vitamin D Supplementation Prevent Progression of Knee Osteoarthritis? A Randomised Controlled Trial

TypeinterventionalSponsorMenzies Institute for Medical ResearchRan2010 to 2014Enrolled413ConditionsOsteoarthritis, KneeArmsVitamin D, Placebo
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Advances in cartilage imaging techniques.Nature reviews. Rheumatology · 2026
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Tian WangMenzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia.ORCID https://orcid.org/0000-0001-6136-9117
Shuang ZhengDepartment of Rheumatology, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
Xingzhong JinCentre for Big Data Research in Health, University of New South Wales, Kensington, New South Wales, Australia.ORCID https://orcid.org/0000-0003-4293-8665
Han CenClinical Research Center, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong, China.
Zhaohua ZhuClinical Research Center, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong, China.
Weiyu HanClinical Research Center, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong, China.
Anita WlukaMenzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia.ORCID https://orcid.org/0000-0001-8024-9049
Flavia CicuttiniMenzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia.
Peihua CaoMenzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia.ORCID https://orcid.org/0000-0003-4269-3899
Changhai DingClinical Research Center, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong, China.ORCID https://orcid.org/0000-0002-9479-730X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: To examine whether the baseline vitamin D level modifies the effects of vitamin D supplementation on knee symptoms and cartilage loss in patients with symptomatic knee OA. Methods: This was a post hoc analysis for the VIDEO study, which was a large ( Results: A total of 413 participants (mean age 63.2 years; 50% women) were randomly assigned to vitamin D and placebo groups. A baseline 25(OH)D level of 43 nmol/l was found as the cut-off value. For the total WOMAC score, vitamin D supplementation decreased more than placebo in patients with 25(OH)D levels of 12.5-43 nmol/l (-256.41 Conclusion: Supplementation of vitamin D in patients with OA who have 25(OH)D levels ≤43 nmol/l could relieve pain and improve physical function, while in OA patients with 25(OH)D levels >43 nmol/l, supplementation may ameliorate cartilage lesions. Trial registration: clinicaltrials.gov, NCT01176344; anzctr.org.au, ACTRN12610000495022.

Indexed as

25(OH)Dcut-off valuekneeorthopaedicsosteoarthritisrheumatologysupplementationsymptomaticvitamin D

Identifiers

PMID40677617
PMCPMC12267135

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.