ArticleThe journal of allergy and clinical immunology. Global2025
Chromosome 21 variants tied to severe asthma exacerbations: A genome-wide association study in a Brazilian population.
Article in The journal of allergy and clinical immunology. Global, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Asthma exacerbations are episodes of symptom worsening requiring increased therapy, which affect patients across all asthma severities. Potential genetic associations with asthma exacerbations in an understudied population were investigated. Objective: We sought to perform a genome-wide association study on severe asthma exacerbations in an admixed adult population with varying asthma severities and to explore potential epigenetic roles. Methods: A genome-wide association study was conducted in 727 Brazilian patients (mean age, 43 years; 20% male; and 55% with exacerbations) from the Programa de Controle da Asma na Bahia study, analyzing 12 million variants. Severe exacerbation was defined as systemic corticosteroid use for 3 or more days, emergency room visits, or hospital admissions within the past year. Analyses were adjusted for age, sex, asthma severity, and genotype principal components. Replication was sought in the cohorts of the Unbiased Biomarkers for the Prediction of Respiratory Disease Outcomes (UBIOPRED) study, the Genes-environments and Admixture in Latino Americans II study, and the Study of African Americans, Asthma, Genes, and Environments using the same methodology. Epigenetic effects were assessed Results: Five intergenic variants (rs55670125, rs10854420, rs68160941, rs11910414, and rs35834033) in complete linkage disequilibrium reached genome-wide significance (odds ratio [OR], 2.5; Conclusions: The CXADR is highlighted as a potential novel susceptibility locus for asthma exacerbations, possibly tied to viral respiratory infections. Further replication and validation are needed.
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