ArticleWorld journal of gastrointestinal endoscopy2025
Endocytoscopy in real-time assessment of histological and endoscopic activity in ulcerative colitis.
Article in World journal of gastrointestinal endoscopy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Association between mucus phenotypes, histopathological features, and ultra-high magnification endoscopic findings in ulcerative colitis.Scientific reports · 2026Article
- New Technologies for IBD Endoscopy.Journal of clinical medicine · 2026Review
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEndocytoscopy is an advanced imaging modality that provides real-time, ultra-high magnification views of the intestinal mucosa. In ulcerative colitis (UC), the combined assessment of endoscopic and histological remission is now becoming a standard practice. However, histological evaluation typically falls outside the scope of the endoscopist. By offering
aimTo evaluate the utility of real-time endocytoscopy in assessing endoscopic and histological disease activity in UC, and to validate endocytoscopic scoring systems.
methodsThis study was conducted at Concord Hospital. Patients with UC who consented to undergo colonoscopy with endocytoscopy were enrolled. Data collected included patient demographics, clinical disease activity, Mayo endoscopic score (MES), and endocytoscopic features such as crypt architecture, intercrypt distance and cellular infiltration. Correlation between endocytoscopic findings were evaluated against MES and the Nancy histological index. Agreement and validation were assessed using the ErLangen Endocytoscopy in ColiTis (ELECT) score and the endocytoscopy score (ECSS), applying Kappa (
resultsA total of 61 colonic segments from 15 patients were assessed, with 187 analyzable endocytoscopic images. Endocytoscopy showed significant correlation with the MES using both the ECSS (
conclusionEndocytoscopy allows for real-time, simultaneous assessment of endoscopic and histological activity in UC and has been proven to be accurate, safe, and well-tolerated. Compared with the ECSS, the ELECT score showed superior concordance with histological findings.
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