Evidence map›Paper›PMID 40677541›Full record

ArticleJournal of traditional and complementary medicine2025

Antcin-H, a natural triterpene derived from

Wei-Ting Wong, Lan-Hui Li, Hsiao-Wen Chiu, Mridula P Menon, Hsien-Ta Hsu, Wen-Yu Lin, Chun-Hsien Wu, Chen-Lung Ho, Kuo-Feng Hua

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of traditional and complementary medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Wei-Ting WongDepartment of Biotechnology and Animal Science, National Ilan University, Ilan, Taiwan.
Lan-Hui LiDepartment of Laboratory Medicine, Linsen, Chinese Medicine and Kunming Branch, Taipei City Hospital, Taipei, Taiwan.
Hsiao-Wen ChiuDepartment of Biotechnology and Animal Science, National Ilan University, Ilan, Taiwan.
Mridula P MenonDepartment of Biotechnology and Animal Science, National Ilan University, Ilan, Taiwan.
Hsien-Ta HsuDivision of Neurosurgery, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan.
Wen-Yu LinDepartment of Biotechnology and Animal Science, National Ilan University, Ilan, Taiwan.
Chun-Hsien WuDivision of Cardiology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Chen-Lung HoDivision of Wood Cellulose, Taiwan Forestry Research Institute, Taipei, Taiwan.
Kuo-Feng HuaDepartment of Biotechnology and Animal Science, National Ilan University, Ilan, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inflammatory bowel disease (IBD) comprises idiopathic intestinal disorders, including ulcerative colitis and Crohn's disease. Patients with IBD experience a significantly reduced quality of life, and effective management remains challenging. The NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) inflammasome controls the expression of the pro-inflammatory cytokines interleukin (IL)-1β and IL-18. Abnormal activation of the NLRP3 inflammasome is a crucial factor in the pathogenesis of IBD, making it an attractive therapeutic target. We discovered that Antcin-H, a triterpene isolated from the unique medicinal fungus

Indexed as

Antcin-HAntrodia cinnamomeaInflammatory bowel diseaseNLRP3 inflammasome

Identifiers

PMID40677541
PMCPMC12266280

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.