ArticleFrontiers in cellular and infection microbiology2025
Association between vaginal microecological alterations and high-risk human papillomavirus infection: a cross-sectional study.
Article in Frontiers in cellular and infection microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Review
- Vaginal microecological diversity and Ureaplasma urealyticum co-infection in high-risk HPV infection: a cross-sectional study.Frontiers in cellular and infection microbiology · 2026Article
- Identification of key vaginal microbial signatures and immune remodeling associated with HR-HPV clearance following Kushen Gel treatment: a longitudinal analysis.Frontiers in medicine · 2026Article
- Construction of a risk prediction model for premature rupture of membranes based on vaginal microecology and systemic inflammation: a prospective cohort study.Frontiers in cellular and infection microbiology · 2026Article
- Microbial regulators of physiological and reproductive health in women of reproductive age: their local, proximal and distal regulatory roles.NPJ biofilms and microbiomes · 2025Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: This study aimed to investigate the correlation between alterations in the vaginal microecological environment and high-risk human papillomavirus (HR-HPV) infection, thereby providing a theoretical basis for clinical prevention and early intervention. Methods: A total of 854 patients who visited the gynecology outpatient clinic at Wusong Central Hospital, Baoshan District, Shanghai, between June and December 2023 were included. Vaginal secretions were collected for HPV genotyping and microecological analysis. Patients were categorized into HR-HPV-positive (n=222) and HR-HPV-negative (n=632) groups. The detection rates of various HR-HPV subtypes (HPV 16, 18, 31, 33, 35, 39, 45, 51, 52, 53, 56, 58, 59, 66, 68, 73, 82) were analyzed. Key microecological indicators-including vaginal pH, hydrogen peroxide, leukocyte esterase, sialidase, Results: Significant differences were observed between the two groups in terms of vaginal pH, hydrogen peroxide, leukocyte esterase, sialidase activity, Conclusion: Changes in the vaginal microecological environment are significantly associated with HR-HPV infection. Monitoring vaginal microecological indicators may provide adjunctive information for clinical prevention and early intervention, though further prospective studies are needed to establish causality.
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