Evidence map›Paper›PMID 40677515›Full record

ArticleDigital health

Feasibility of evaluating AI-enabled digital symptom monitoring in metastatic patients with NSCLC receiving pembrolizumab therapy: A German single-arm observational pilot study.

Melissa L Santorelli, Oliver Schmalz, Mathias Hoiczyk, David Heigener, Clemens Schulte, Markus Knott, Petra Hoffknecht, Joonas Vainio, Thomas Burke, Josephine M Norquist and 4 more

Abstract read
In one paragraph

Article in Digital health. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Melissa L SantorelliMerck & Co., Inc., Rahway, NJ, USA.
Oliver SchmalzHELIOS Universitätsklinikum Wuppertal, Klinik für Hämatologie, Onkologie und Palliativmedizin, Wuppertal, Germany.
Mathias HoiczykMedizinisches Versorgungszentrum (MVZ) Marien-Hospital-Wesel GmbH, Wesel, Germany.
David HeigenerZentrum für Pneumologie, Agaplesion Diakonieklinikum Rotenburg gGmbH, Rotenburg, Germany.
Clemens SchulteGemeinschaftspraxis für Hämatologie und Onkologie, Gefos Dortmund mbH, Dortmund, Germany.
Markus KnottStuttgart Cancer Center, Klinikum der Landeshauptstadt Stuttgart gKAöR, Stuttgart, Germany.
Petra HoffknechtMedizinisches Versorgungszentrum (MVZ) II - Onkologie und Hämatologie, MVZ Niels-Stensen-Kliniken, Georgsmarienhütte, Germany.
Joonas VainioElekta Oy, Helsinki, Finland.
Thomas BurkeMerck & Co., Inc., Rahway, NJ, USA.
Josephine M NorquistMerck & Co., Inc., Rahway, NJ, USA.
Sabine RiehlClinical Research, Alcedis GmbH, Gießen, Germany.ORCID https://orcid.org/0009-0000-3212-0558
Alexander HildnerClinical Research, Alcedis GmbH, Gießen, Germany.
Lisa BarthuberReal World Evidence, MSD Sharp & Dohme GmbH, Munich, Germany.
Sabine BohnetUKSH, Campus Lübeck, Lübeck, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Close symptom monitoring can benefit patients with metastatic nonsmall cell lung cancer (mNSCLC) receiving first-line therapy. Remote patient monitoring technologies, like the artificial intelligence (AI)-enabled Kaiku Methodology: The lung artificial intelligence-enabled digital solution pilot study ("Lung AID") assessed the feasibility of future studies on Kaiku Results: Over a 17-month enrollment period, 47 of 100 planned patients were enrolled in the study. Kaiku Discussion: High Kaiku Conclusion: While definitive conclusions on future studies cannot be drawn, the study offers key insights into challenges that should be considered in future research.

Indexed as

AINSCLCpembrolizumabPROreal-worldremote symptom monitoring

Identifiers

PMID40677515
PMCPMC12268122

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.