ArticleCureus2025
Bedside Ultrasonographic Measurement of Optic Nerve Sheath Diameter for Assessing Increased Intracranial Pressure: An Observational Study.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
Background Traumatic brain injury (TBI) is a leading cause of disability and mortality, particularly in resource-limited settings where advanced neuromonitoring tools are often unavailable. Elevated intracranial pressure (ICP) is a serious and potentially life-threatening complication of TBI. Traditional methods for monitoring ICP are invasive, expensive, and require specialized expertise. Ultrasonographic measurement of the optic nerve sheath diameter (ONSD) offers a noninvasive, real-time, and radiation-free alternative for assessing ICP. Objective This study aimed to evaluate the diagnostic accuracy of bedside ONSD measurement in detecting elevated ICP among neurotrauma patients, using CT imaging as the reference standard. Additionally, it explored the relationship between ONSD measurements, TBI severity, and neurological outcomes. Methods A prospective observational study was conducted on 100 adult patients with TBI, in whom bilateral ONSD measurements were obtained using a high-frequency linear ultrasound probe. Based on CT scan findings, patients were classified as having either raised or normal ICP. Statistical analyses included sensitivity, specificity, positive and negative predictive values, receiver operating characteristic curve analysis, and logistic regression to assess the diagnostic and prognostic utility of ONSD. Results Raised ICP was observed in 67% of patients, most of whom had moderate to severe TBI. ONSD values increased with injury severity: mild (4.53 ± 0.14 mm), moderate (5.24 ± 0.15 mm), and severe (5.90 ± 0.25 mm). A cutoff value of 5.2 mm demonstrated 95.5% sensitivity, 93.9% specificity, and an area under the curve of 0.96. An ONSD greater than 5.5 mm was strongly associated with poor neurological outcomes (Glasgow Outcome Scale scores 1-3), with an OR of 4.6 (p < 0.001). Conclusions Bedside ultrasonographic measurement of ONSD is a reliable and accurate method for detecting elevated ICP in TBI patients. It correlates strongly with both injury severity and clinical outcomes, making it a valuable tool in emergency and intensive care settings. Further studies comparing this technique with invasive monitoring methods and evaluating long-term outcomes are warranted.
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