ArticleCureus2025
A Prospective Analysis of Risk Factors and Outcomes of Intracranial Atherosclerosis.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Association between cardiovascular disease risk, regional brain age gap, and cognition in healthy adults.Frontiers in aging neuroscience · 2025Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionIntracranial atherosclerosis (ICAS) is a progressive disease that leads to narrowing of the brain's arteries and reduced blood flow, making it a leading cause of both initial and recurrent strokes worldwide. Various contributing factors influence its development. Despite advanced neuroimaging and therapeutic interventions, the management of ICAS remains a concern. Our study examines the risk factors and outcomes of ischemic stroke due to ICAS in a tertiary care facility.
methodsThis prospective study examines 100 patients with ICAS-related acute ischemic stroke. Diagnosis was established by magnetic resonance angiography (MRA). Clinical assessments, imaging studies, laboratory tests, and follow-up evaluations were performed over a 12-month period. Recurrence of stroke and function status were evaluated using multivariate Cox regression analysis and Kaplan-Meier survival curves.
resultsDominant risk factors were hypertension, seen in 82 (82%) patients, followed by diabetes mellitus, which was seen in 52 (52%) patients. Smoking as a risk factor was reported in 34 (34%) cases, followed by hyperlipidemia, which was seen in 29 (29%) cases. The middle cerebral artery was involved in 53 (53%) patients. Stroke recurrence occurred in 17 (17%) patients within the first three months. The independent presence of three or more risk factors raised recurrence risk (p=0.035). Dual antiplatelet and statin therapies significantly reduced recurrence (p<0.05). Smoking and higher National Institutes of Health Stroke Scale (NIHSS) scores were linked to worse functional outcomes.
conclusionThis study confirms a greater prevalence of intracranial atherosclerotic stroke among men. Intensive medical treatment, such as incorporating dual antiplatelet therapy, statins, and strict management of diabetes and hypertension, showed a significant reduction in recurrence rates.
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