Evidence map›Paper›PMID 40677394›Full record

ArticleMaterials today. Bio2025

Deliver CEBPE via cartilage targeting Lipid nanoparticle to block CEBPE-LTF-STAT3 positive feedback loop for efficient treatment of cartilage endplate degeneration.

Jiangminghao Zhao, Peichuan Xu, Tao Li, Jinghong Yuan, Wenrui Zhao, Rui Ding, Guoyu Yang, Jiajun Xie, Guanfeng Huang, Zhidong Peng and 2 more

Abstract read
In one paragraph

Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jiangminghao ZhaoDepartment of Orthopaedics, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Peichuan XuDepartment of Orthopaedics, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Tao LiDepartment of Orthopaedics, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Jinghong YuanDepartment of Orthopaedics, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Wenrui ZhaoJiangxi Provincial Key Laboratory of Spine and Spinal Cord Disease, Nanchang University, Nanchang, China.
Rui DingDepartment of Orthopaedics, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Guoyu YangDepartment of Orthopaedics, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Jiajun XieDepartment of Orthopaedics, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Guanfeng HuangDepartment of Orthopaedics, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Zhidong PengDepartment of Orthopaedics, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Xinxin MiaoDepartment of Orthopaedics, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Xigao ChengDepartment of Orthopaedics, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intervertebral disc degeneration (IVDD) is recognized as a significant underlying factor contributing to clinical neck and low back pain. The cartilaginous endplates (CEP) serve as a selectively permeable barrier, which is essential for maintaining the internal homeostasis of the intervertebral disc (IVD). Dysfunction of the CEP is closely related to the initiation and progression of IVDD. In this paper, we demonstrate that CCAAT enhancer-binding protein

Indexed as

Cartilage targetingCEBPEIntervertebral disc degenerationJAK2/STAT3 inflammatory signaling pathwayLipid nanoparticleLTF

Identifiers

PMID40677394
PMCPMC12268938

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.