ArticleMaterials today. Bio2025
Multifunctional hydrogel promotes rotator cuff healing through anti-inflammation and vascularization.
Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Antifibrotic hydrogel strategies for scarless tissue regeneration: mechanisms, design, and application.Bioactive materials · 2027Review
- Review
- Glycosaminoglycans in tissue regeneration: Insights into glycobiology and their biomedical application.Bioactive materials · 2026Review
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rotator cuff tears (RCTs) represent a substantial clinical challenge due to their intricate, multi-stage healing process, which encompasses sequential phases of inflammation, proliferation, tissue reconstruction, and remodeling. Disruption of any phase can adversely affect healing and increase the risk of re-tear. To address this issue, we engineered an injectable LA-CMCS-OHA hydrogel by physically blending lactic acid (LA)-a key signaling molecule-into a composite hydrogel system consisting of carboxymethyl chitosan (CMCS) and oxidized hyaluronic acid (OHA). The hydrogel formation was facilitated by a dynamic Schiff base reaction between CMCS and OHA, imparting superior biocompatibility, injectability, and self-healing properties. The LA-CMCS-OHA hydrogel effectively inhibits nuclear factor kappa B (NF-κB) signaling, thereby promoting macrophage polarization toward the anti-inflammatory M2 phenotype and mitigating early inflammatory responses. Additionally, it markedly enhances vascular endothelial growth factor (VEGF) expression, stimulating the proliferation and migration of human umbilical vein endothelial cells (HUVECs) to facilitate neovascularization. These therapeutic effects were comprehensively validated through both in
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Registered trials
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