Evidence map›Paper›PMID 40677383›Full record

ArticleBiomedical optics express2025

High-resolution multimodal visible light optical coherence tomography and scanning laser ophthalmoscopy for

Siyu Song, Guangru Ben Liang, Tristan T Hormel, Yukun Guo, Min Gao, Benjamin Sivyer, J Peter Campbell, Siyu Chen, Yifan Jian, Yali Jia

Abstract read
In one paragraph

Article in Biomedical optics express, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. 100-degree Non-Contact Retinal Imaging in Mice Using a Multimodal Vis-OCT and SLO System.IEEE photonics technology letters : a publication of the IEEE Laser and Electro-optics Society · 2026
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Siyu SongCasey Eye Institute, Oregon Health & Science University, Portland, Oregon, USA.
Guangru Ben LiangCasey Eye Institute, Oregon Health & Science University, Portland, Oregon, USA.ORCID https://orcid.org/0000-0002-6322-3899
Tristan T HormelCasey Eye Institute, Oregon Health & Science University, Portland, Oregon, USA.
Yukun GuoCasey Eye Institute, Oregon Health & Science University, Portland, Oregon, USA.ORCID https://orcid.org/0000-0002-6784-2355
Min GaoCasey Eye Institute, Oregon Health & Science University, Portland, Oregon, USA.ORCID https://orcid.org/0000-0002-0344-0162
Benjamin SivyerCasey Eye Institute, Oregon Health & Science University, Portland, Oregon, USA.
J Peter CampbellCasey Eye Institute, Oregon Health & Science University, Portland, Oregon, USA.
Siyu ChenCasey Eye Institute, Oregon Health & Science University, Portland, Oregon, USA.ORCID https://orcid.org/0000-0003-0336-3627
Yifan JianCasey Eye Institute, Oregon Health & Science University, Portland, Oregon, USA.
Yali JiaCasey Eye Institute, Oregon Health & Science University, Portland, Oregon, USA.ORCID https://orcid.org/0000-0002-2784-1905

Funding

Proteomics CoreP30EY010572 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI Kate E Keller · 1995 to 2026
$19.4M
OCT Angiography for Neovascular Age-related Macular DegenerationR01EY024544 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI Steven T Bailey, Yali Jia · 2014 to 2026
$6.2M
OCTA Precursors of Vision-Threatening Complications of Diabetic RetinopathyR01EY035410 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI Thomas Hwang, Yali Jia · 2023 to 2026
$2.5M
Translational Vision Science Research at Oregon Health & Science UniversityT32EY023211 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI Yali Jia, Kate E Keller · 2013 to 2026
$2.4M
Advancing visible-light OCT in oxygen-induced retinopathyR01EY036429 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI John Peter Campbell, Yali Jia · 2024 to 2026
$2.0M
Visible-light OCT angiography, velocimetry, and oximetry for characterizing retinal vascular alterations in glaucomaR01EY031394 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI JIA, YALI, MORRISON, JOHN C · 2020 to 2022
$1.6M
A diagnostic platform for diabetic retinopathy based on OCT angiography and artificial intelligenceR43EY036781 · NEI · IFOCUS IMAGING LLC · PI HORMEL, TRISTAN, JIA, YALI · 2024 to 2024
$306k
NEI NIH HHS P30 EY010572NEI NIH HHS R01 EY024544NEI NIH HHS R01 EY031394NEI NIH HHS R01 EY035410NEI NIH HHS R01 EY036429NEI NIH HHS R43 EY036781NEI NIH HHS T32 EY023211
6 · The paper itself

Abstract

Microglial cells play a crucial role in retinal vascular and brain diseases through complex interactions with blood vessels and neurons. To image retinal structures, vasculature, and microglia, we developed a multimodal system integrating visible light optical coherence tomography (vis-OCT) and scanning laser ophthalmoscopy (SLO). Both subsystems achieve micron-scale resolutions and operate within the diffraction limit across a 34-degree field of view: theoretically, the OCT system offers an axial resolution of 2.12 μm and a transverse resolution of 8.78 μm, while the SLO system provides a transverse resolution of 7.1 μm. We validated the system performance using transgenic mice with fluorescent protein-labeled microglia, revealing detailed retinal microstructures, microvasculature, and individual microglia with distinguishable branches, confirmed by

Identifiers

PMID40677383
PMCPMC12265451

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.