Evidence map›Paper›PMID 40677337›Full record

ArticleKidney international reports2025

Acute Effect of High Fat Intake on Urinary Acidification Parameters.

Alireza Zomorodian, Xilong Li, John Poindexter, Naim M Maalouf, Orson W Moe, Khashayar Sakhaee

Abstract read
In one paragraph

Article in Kidney international reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Alireza ZomorodianCharles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Xilong LiPeter J. O'Donnell Jr. School of Public Health, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
John PoindexterCharles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Naim M MaaloufCharles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Orson W MoeCharles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Khashayar SakhaeeCharles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

Funding

Pathogenesis of Uric Acid Nephrolithiasis: The Multifaceted Role of Renal LipidsR01DK081423 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI MAALOUF, NAIM M, MOE, ORSON W · 2009 to 2023
$6.1M
Origin of Excess Acid in Uric Acid UrolithiasisR01DK115703 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI BROWNING, JEFFREY D, MOE, ORSON W · 2019 to 2023
$2.2M
NIDDK NIH HHS R01 DK081423NIDDK NIH HHS R01 DK115703
6 · The paper itself

Abstract

Introduction: The prevalence of uric acid nephrolithiasis has increased contemporaneously with obesity. The key pathogenic factor in uric acid nephrolithiasis is acidic urine pH (UpH), which partially results from reduced buffering of H Methods: Seven UASFs and 8 Ctrls were equilibrated on a fixed metabolic diet for 4 days. After sampling fasting urine and blood, the subjects received oral fat load over 10 hours, with blood and urine samples collected every 2 hours. Results: Both groups exhibited significant and similar increases in serum FFAs. UpH progressively decreased from 6.6 to 5.6 in the Ctrl group over 10 hours ( Conclusion: In conclusion, Ctrls showed reduced NH

Indexed as

acid-basefree fatty acidmetabolic syndromeuric acidurolithiasis

Identifiers

PMID40677337
PMCPMC12266272

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.