Evidence map›Paper›PMID 40677234›Full record

ArticleHypertension (Dallas, Tex. : 1979)2025

Targeting N

Hui Liu, Ling Zhang, Zhen Lin, Zhiyuan Liu, Guangyu Hu, Xiyao Chen, Congye Li, Fangfang Sun, Xiong Guo, Chong Huang and 10 more

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In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

20 authors.

Hui Liu *Department of Cardiology (H.L., L.Z., Z. Lin, Z. Liu, G.H., C.L., F.S., X.G., C.H., Z.C., X.W., Z.W., X.Z., Y.W., Y.X., W.Y., S.W., F.Z., L.T.), Xijing Hospital, Fourth Military Medical University, China.ORCID 0009-0008-7644-208X
Ling Zhang *Department of Cardiology (H.L., L.Z., Z. Lin, Z. Liu, G.H., C.L., F.S., X.G., C.H., Z.C., X.W., Z.W., X.Z., Y.W., Y.X., W.Y., S.W., F.Z., L.T.), Xijing Hospital, Fourth Military Medical University, China.ORCID 0000-0001-8850-9706
Zhen Lin *Department of Cardiology (H.L., L.Z., Z. Lin, Z. Liu, G.H., C.L., F.S., X.G., C.H., Z.C., X.W., Z.W., X.Z., Y.W., Y.X., W.Y., S.W., F.Z., L.T.), Xijing Hospital, Fourth Military Medical University, China.
Zhiyuan Liu *Department of Cardiology (H.L., L.Z., Z. Lin, Z. Liu, G.H., C.L., F.S., X.G., C.H., Z.C., X.W., Z.W., X.Z., Y.W., Y.X., W.Y., S.W., F.Z., L.T.), Xijing Hospital, Fourth Military Medical University, China.
Guangyu HuDepartment of Cardiology (H.L., L.Z., Z. Lin, Z. Liu, G.H., C.L., F.S., X.G., C.H., Z.C., X.W., Z.W., X.Z., Y.W., Y.X., W.Y., S.W., F.Z., L.T.), Xijing Hospital, Fourth Military Medical University, China.ORCID 0000-0002-9091-4484
Xiyao ChenDepartment of Geriatrics (X.C.), Xijing Hospital, Fourth Military Medical University, China.
Congye LiDepartment of Cardiology (H.L., L.Z., Z. Lin, Z. Liu, G.H., C.L., F.S., X.G., C.H., Z.C., X.W., Z.W., X.Z., Y.W., Y.X., W.Y., S.W., F.Z., L.T.), Xijing Hospital, Fourth Military Medical University, China.
Fangfang SunDepartment of Cardiology (H.L., L.Z., Z. Lin, Z. Liu, G.H., C.L., F.S., X.G., C.H., Z.C., X.W., Z.W., X.Z., Y.W., Y.X., W.Y., S.W., F.Z., L.T.), Xijing Hospital, Fourth Military Medical University, China.
Xiong GuoDepartment of Cardiology (H.L., L.Z., Z. Lin, Z. Liu, G.H., C.L., F.S., X.G., C.H., Z.C., X.W., Z.W., X.Z., Y.W., Y.X., W.Y., S.W., F.Z., L.T.), Xijing Hospital, Fourth Military Medical University, China.
Chong HuangDepartment of Cardiology (H.L., L.Z., Z. Lin, Z. Liu, G.H., C.L., F.S., X.G., C.H., Z.C., X.W., Z.W., X.Z., Y.W., Y.X., W.Y., S.W., F.Z., L.T.), Xijing Hospital, Fourth Military Medical University, China.
Zhe CuiDepartment of Cardiology (H.L., L.Z., Z. Lin, Z. Liu, G.H., C.L., F.S., X.G., C.H., Z.C., X.W., Z.W., X.Z., Y.W., Y.X., W.Y., S.W., F.Z., L.T.), Xijing Hospital, Fourth Military Medical University, China.ORCID 0000-0002-1993-2137
Xinyi WangDepartment of Cardiology (H.L., L.Z., Z. Lin, Z. Liu, G.H., C.L., F.S., X.G., C.H., Z.C., X.W., Z.W., X.Z., Y.W., Y.X., W.Y., S.W., F.Z., L.T.), Xijing Hospital, Fourth Military Medical University, China.
Zhengyang WangDepartment of Cardiology (H.L., L.Z., Z. Lin, Z. Liu, G.H., C.L., F.S., X.G., C.H., Z.C., X.W., Z.W., X.Z., Y.W., Y.X., W.Y., S.W., F.Z., L.T.), Xijing Hospital, Fourth Military Medical University, China.ORCID 0009-0000-3225-5954
Xutong ZhangDepartment of Cardiology (H.L., L.Z., Z. Lin, Z. Liu, G.H., C.L., F.S., X.G., C.H., Z.C., X.W., Z.W., X.Z., Y.W., Y.X., W.Y., S.W., F.Z., L.T.), Xijing Hospital, Fourth Military Medical University, China.
Yile WuDepartment of Cardiology (H.L., L.Z., Z. Lin, Z. Liu, G.H., C.L., F.S., X.G., C.H., Z.C., X.W., Z.W., X.Z., Y.W., Y.X., W.Y., S.W., F.Z., L.T.), Xijing Hospital, Fourth Military Medical University, China.
Yunlong XiaDepartment of Cardiology (H.L., L.Z., Z. Lin, Z. Liu, G.H., C.L., F.S., X.G., C.H., Z.C., X.W., Z.W., X.Z., Y.W., Y.X., W.Y., S.W., F.Z., L.T.), Xijing Hospital, Fourth Military Medical University, China.
Wenjun YanDepartment of Cardiology (H.L., L.Z., Z. Lin, Z. Liu, G.H., C.L., F.S., X.G., C.H., Z.C., X.W., Z.W., X.Z., Y.W., Y.X., W.Y., S.W., F.Z., L.T.), Xijing Hospital, Fourth Military Medical University, China.
Shan WangDepartment of Cardiology (H.L., L.Z., Z. Lin, Z. Liu, G.H., C.L., F.S., X.G., C.H., Z.C., X.W., Z.W., X.Z., Y.W., Y.X., W.Y., S.W., F.Z., L.T.), Xijing Hospital, Fourth Military Medical University, China.ORCID 0000-0002-9487-0829
Fuyang ZhangDepartment of Cardiology (H.L., L.Z., Z. Lin, Z. Liu, G.H., C.L., F.S., X.G., C.H., Z.C., X.W., Z.W., X.Z., Y.W., Y.X., W.Y., S.W., F.Z., L.T.), Xijing Hospital, Fourth Military Medical University, China.ORCID 0000-0002-6335-9809
Ling TaoDepartment of Cardiology (H.L., L.Z., Z. Lin, Z. Liu, G.H., C.L., F.S., X.G., C.H., Z.C., X.W., Z.W., X.Z., Y.W., Y.X., W.Y., S.W., F.Z., L.T.), Xijing Hospital, Fourth Military Medical University, China.ORCID 0000-0002-7076-1185

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHypertension is a significant global health issue that contributes to chronic kidney disease (CKD). Mitochondrial dysfunction in renal tubular epithelial cells (TECs) plays a crucial role in the progression of CKD. However, the involvement of mitochondrial DNA (mtDNA) methylation in hypertensive CKD and its potential as a therapeutic target remains largely unexamined.

methodsA hypertensive CKD mouse model was induced by continuous infusion of AngII (angiotensin II). Renal mtDNA methylation types and levels were evaluated using nanopore sequencing and dot blot assays. The impact of N

resultsUtilizing high-confidence Nanopore sequencing, we identified 6mA as the predominant methylation type in renal mtDNA, rather than 5-methylcytosine. In mice with hypertensive CKD, renal mtDNA 6mA levels significantly increased, while 5-methylcytosine levels remained stable. METTL4, the only known mammalian methyltransferase for 6mA, was upregulated in the renal tubules of hypertensive CKD mice and patients with hypertension. AngII stimulation increased METTL4 expression and mtDNA 6mA levels in primary TECs. Activated c-Jun/AP-1 (activator protein-1) directly promoted Mettl4 transcription in AngII-treated primary TECs. METTL4-catalyzed mtDNA 6mA impeded mitochondrial transcription initiation complex assembly, thereby halting mtDNA transcription, disrupting mitochondrial function, and resulting in the transition of TECs into a proinflammatory and profibrotic phenotype. TEC-specific

conclusionsThis study reveals that METTL4-catalyzed mtDNA 6mA contributes to renal mitochondrial dysfunction and hypertensive CKD, offering novel therapeutic strategies from the perspective of mitochondrial epigenetics.

Indexed as

AdenineDNA, MitochondrialHypertensionKidney TubulesMethyltransferasesRenal Insufficiency, ChronicAngiotensin IIAnimalsDisease Models, AnimalDNA MethylationHumansMaleMiceMice, Inbred C57BLMice, KnockoutMitochondriaAdenineAngiotensin IIDNA, MitochondrialMethyltransferasesDNA, mitochondrialepithelial cellshypertensionkidneymethyltransferases

Identifiers

PMID40677234
PMCPMC12366740

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.